Actively Recruiting

Age: 18Years +
All Genders
ID06531005

Assessment of Ventilation Parameters for Extubation Prediction in ICU

Led by Ankara University · Updated on 2024-07-31

100

Participants Needed

1

Research Sites

4 weeks

Total Duration

On this page

Sponsors

A

Ankara University

Lead Sponsor

G

Gazi University

Collaborating Sponsor

AI-Summary

What this Trial Is About

Researchers are studying how different ventilation parameters like mechanical power, driving pressure, and elastic power can help predict how long critically ill patients on invasive mechanical ventilation will need support. This observational study includes patients recently intubated for acute respiratory failure and aims to improve decisions about when to safely remove breathing tubes or prepare for alternatives like tracheostomy. The study monitors these ventilation values at the start of mechanical ventilation, and again at 24 and 48 hours, to see how well they predict extubation within the first week. By including all patients on invasive ventilation, the research looks beyond specific conditions like ARDS to better understand risks across a broad ICU population. Participants will be observed during their ICU stay with regular assessments of their ventilator settings and clinical condition. Researchers will track outcomes such as the timing of extubation within seven days, mortality at 28 days, development of acute kidney failure within a month, and length of ICU or hospital stay over three months. This approach aims to guide early treatment planning and improve patient management in critical care.

CONDITIONS

Brief Title

Assessment of Ventilation Parameters for Extubation Prediction in ICU

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Consenting patients who have recently been intubated for acute respiratory failure
  • Age 18 years or older
Not Eligible

You will not qualify if you...

  • Patients with lung cancer or lung metastasis
  • Patients receiving extracorporeal membrane oxygenation (ECMO)
  • Patients expected to die within 24 hours

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Monitoring

Duration - First 7 days after intubation

Participants who are under invasive mechanical ventilation have their ventilation parameters measured and monitored at specific timepoints to predict extubation within the first week.

Visits at 0, 24, and 48 hours after intubation

Long-term Monitoring

Duration - Up to 3 months

Participants are observed for clinical outcomes including mortality, acute renal failure, and length of ICU/hospital stay.

Follow-up visits up to 3 months after intubation

Trial Site Locations

Total: 1 location

1

Ankara University Faculty of Medicine

Altindağ, Ankara, Turkey (Türkiye), 06230

Actively Recruiting

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Research Team

N

nuri işler, res.doctor

N

Nazlıhan B DÜNDAR, Ass.Prof.

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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Published Research Related To This Trial

Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome.

Acute Respiratory Distress Syndrome Network, Roy G Brower, Michael A Matthay...

https://pubmed.ncbi.nlm.nih.gov/10793162

ARDSNet lower tidal volume ventilatory strategy may generate intrinsic positive end-expiratory pressure in patients with acute respiratory distress syndrome.

Gabriella de Durante, Monica del Turco, Laura Rustichini...

https://pubmed.ncbi.nlm.nih.gov/11991877

Static and Dynamic Contributors to Ventilator-induced Lung Injury in Clinical Practice. Pressure, Energy, and Power.

John J Marini, Patricia R M Rocco, Luciano Gattinoni

https://pubmed.ncbi.nlm.nih.gov/31665612