Autonomic Effects of Transcutaneous Spinal Cord Stimulation in Veterans With Spinal Cord Injury (SCI)

What this Trial Is About

Researchers are evaluating the effects of transcutaneous spinal cord stimulation (TSCS) on exercise ability and core body temperature regulation in people with chronic spinal cord injury (SCI). This interventional crossover study aims to compare active TSCS targeting blood pressure control with sham TSCS. The study focuses on exercise endurance during arm cycling and heart rate recovery, as well as body temperature responses and comfort in a cool environment. Participants receive both active and sham TSCS delivered through surface electrodes placed on the skin, with stimulation parameters tailored to each individual. The active stimulation lasts 30 minutes, while sham stimulation is applied for only one minute to simulate the experience without therapeutic effect. The study has two parts: one involving arm cycling exercise and another involving exposure to a cool room at 64°F for 90 minutes. Participants may choose to join one or both parts. During the study visits, participants undergo exercise tests and remain seated in controlled temperature rooms while their responses to stimulation are recorded. Assessments include exercise endurance time, heart rate recovery, core body temperature, and thermal comfort ratings. Each part involves two laboratory visits lasting 3-4 hours each. The researchers also measure workload and perceived exhaustion after exercise. The total participation time depends on the parts chosen. There are no expected long-term benefits from participation.

Autonomic Effects of Spinal Cord Stimulation in Spinal Cord Injury