Evaluation of Autonomic Nervous System Involvement in Patients With Cognitive Impairment Using a Non-invasive Study of Dysautonomia

What this Trial Is About

Researchers are evaluating autonomic nervous system involvement in patients with various forms of cognitive decline, including mild cognitive impairment and dementia types such as Alzheimer's, Lewy's body dementia, and Parkinson's dementia. This interventional study uses a device to compare autonomic parameters among these patient groups to better understand the prevalence and characteristics of autonomic dysfunction related to cognitive decline. Participants will undergo assessments using the Sudoscan device, which records sudomotor function and pupillary reactivity, to measure autonomic function. The study compares these autonomic parameters in subjects with different types and severities of cognitive impairment. The primary study period spans an average of three years, during which participants are monitored for changes and correlations between autonomic dysfunction and cognitive decline severity. During the study, participants will be evaluated at baseline and follow-ups for autonomic dysfunction prevalence, cognitive disorder types assessed by MMSE scores, and the relationship between autonomic involvement and cognitive decline severity. Researchers will collect data on autonomic nervous system function and cognitive status to understand their connection better. The study includes continuous monitoring over approximately three years to assess these outcomes comprehensively.

Autonomic Involvement in Patient With Cognitive Decline