Study of Bispectral Index Monitoring Versus Standard Sedation Monitoring in Adults on Mechanical Ventilation in the ICU

What this Trial Is About

This trial investigates the differences in mechanical ventilation duration, ICU length of stay, and sedation medication doses between patients monitored with Bispectral index BIS devices and those who are not. It focuses on patients admitted to a medical ICU who require mechanical ventilation and sedation. The study aims to improve understanding of sedation management by comparing BIS monitoring with standard sedation assessment protocols. Participants are randomly assigned to one of two groups. The BIS group is continuously monitored using the BIS device until extubation, transfer, comfort care, or death. BIS monitoring measures brain activity to assess sedation depth through a numerical scale from 0 to 100. The other group follows usual sedation protocols using scales like Richmond Agitation Sedation Scale RASS or Ramsay Sedation Scale RSS as chosen by the physician. During the study, participants ventilator time, sedation medication amount, and ICU stay length will be recorded. The trial tracks the time from intubation to extubation or other endpoints, typically about 4 to 6 days. Researchers will also monitor sedation levels and ICU discharge timing. The overall study duration for participants corresponds to their ICU stay and ventilation period, with data collection focusing on these key outcomes.

Bispectral Monitoring on Mechanically Ventilated Patients