Blood Flow Restriction Training After Patellar INStability (BRAINS Trial)

What this Trial Is About

This research study investigates whether a new type of physical therapy called blood flow restriction training (BFRT) can improve recovery for people with patellar instability, a condition involving knee dislocation or injury. The study is designed to answer important questions about BFRT's role in rehabilitation by comparing it with standard physical therapy. Participants eligible for the study are aged 14 to 40 years and have a diagnosis of traumatic patellar instability confirmed by a qualified medical professional. Participants are randomly assigned to one of two groups: standard physical therapy alone or standard physical therapy combined with BFRT. BFRT involves using an air cuff inflated around the thigh to limit blood flow during a standardized exercise program, lasting 8 weeks. Physical therapy may include exercises to improve knee strength, hip strength, gait training, and other supportive activities. Both groups receive close monitoring to ensure safety throughout treatment. Participants will attend multiple study visits over two years, starting with screening and enrollment, followed by strength testing, biomechanical assessments, questionnaires, blood and urine sample collection, and MRI scans. These visits occur at 1 week, 5 weeks, 9 weeks, 6 months, 1 year, and 2 years after enrollment. Throughout the study, researchers will measure knee function, strength symmetry, pain levels, and muscle health using tools like the Norwich Patellar Instability Scale and MRI imaging to assess recovery progress.

Blood Flow Restriction Training After Patellar INStability