Ethnic Differences in Incidence and Outcomes of Childhood Nephrotic Syndrome.
Tonny H M Banh, Neesha Hussain-Shamsy, Viral Patel...
https://pubmed.ncbi.nlm.nih.gov/27445165Actively Recruiting
Phase Not Applicable
Age: 2Years - 14Years
All Genders
Healthy Volunteers
ID06622915
Cardiac Performance Evaluation in Children With Steroid Dependent vs Steroid Resistant Nephrotic Syndrome
Led by Sohag University · Updated on 2024-10-02
60
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Nephrotic syndrome is a common kidney disease in children, and patients with primary nephrotic syndrome have a higher risk of developing heart disease compared to the general population. This research evaluates cardiac function in children with two types of nephrotic syndrome: steroid dependent and steroid resistant. The study aims to better understand how heart performance differs between these groups using advanced imaging techniques. The study uses Tissue Doppler imaging alongside Conventional Echocardiography, both non-invasive methods that measure the motion velocity of specific heart structures like the mitral annulus, tricuspid annulus, and interventricular septum. Participants are randomly assigned to one of two groups based on their nephrotic syndrome type: steroid dependent or steroid resistant. These imaging assessments help compare cardiac performance between these groups. Children aged 2 to 14 years with primary nephrotic syndrome will participate, undergoing heart imaging and monitoring over 12 months. Researchers will evaluate cardiac function changes using the specified imaging techniques. Throughout the study, participants' heart health will be closely observed to gather detailed information on cardiac performance related to their nephrotic syndrome type.
CONDITIONS
Brief Title
Cardiac Performance Evaluation in Children With Steroid Dependent vs Steroid Resistant Nephrotic Syndrome
Who Can Participate
Age: 2Years - 14Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Children with primary nephrotic syndrome
- Age between 2 and 14 years
- Both males and females
You will not qualify if you...
- Patients with primary cardiac diseases such as congenital or rheumatic heart disease or cardiomyopathy
- Patients who refuse to give written informed consent to participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Surveillance
Duration - 12 months
Participants who undergo routine care are observed using non-invasive cardiac imaging techniques to evaluate cardiac performance.
Periodic visits for cardiac imaging assessments
Trial Site Locations
Total: 1 location
1
Sohag University hospitals
Sohag, Egypt
Actively Recruiting
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Research Team
A
alaa y Mohamed, Resident
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SCREENING
Number of Arms
2
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Published Research Related To This Trial
Differential right and left ventricular diastolic tolerance to acute afterload and NCX gene expression in Wistar rats.
J Correia Pinto, T Henriques-Coelho, R Roncon-Albuquerque...
https://pubmed.ncbi.nlm.nih.gov/16343035Presence of fragmented QRS and its correlation with myocardial performance index in patients with nephrotic syndrome.
Gülsüm Ozkan, Adem Adar, Sükrü Ulusoy...
https://pubmed.ncbi.nlm.nih.gov/24901023Venous thrombosis in the nephrotic syndrome.
Joseph Loscalzo
https://pubmed.ncbi.nlm.nih.gov/23465106