Aortic Valve Stenosis Causes Accumulation of Extracellular Hemoglobin and Systemic Endothelial Dysfunction.
Christine Quast, Florian Bönner, Amin Polzin...
https://pubmed.ncbi.nlm.nih.gov/38836358Actively Recruiting
Age: 18Years +
All Genders
Healthy Volunteers
ID05603520
Phenotyping Heterogeneity and Regionality of the Aorta
Led by Heinrich-Heine University, Duesseldorf · Updated on 2024-01-10
300
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to understand the differences and regional characteristics of the aorta, the main artery that distributes blood throughout the body. It focuses on how the physical and mechanical properties of the aortic wall vary between regions and how these differences may cause problems like artery stiffening, which can lead to organ damage. The study follows a group of people, including healthy volunteers and patients with aortic conditions, to identify key factors in aortic disease. Participants include healthy volunteers, patients with severe aortic stenosis, and patients with aortic aneurysms. The study collects clinical data systematically over time to observe the progression of conditions affecting the aorta. The study is observational, with no treatments assigned, and focuses on gathering detailed information from participants to better understand aortic health and disease. During the study, researchers will track participants for up to five years, monitoring changes in large artery stiffness, development of aortic aneurysms, heart function measures such as diastolic dysfunction, and blood flow characteristics using MRI scans. Participants will undergo clinical assessments and imaging tests to provide data on their vascular health. This long-term observation aims to identify important changes in aortic conditions and their effects on the body.
CONDITIONS
Brief Title
Phenotyping Heterogeneity and Regionality of the Aorta
Who Can Participate
Age: 18Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Apparently healthy volunteers
- Patients suffering from 3rd degree Aortic Stenosis
- Patients suffering from Aortic Aneurysms
- Participants must be 18 years or older
You will not qualify if you...
- Under 18 years of age
- Taking active medication (for healthy volunteers)
- Having cardiovascular disease (for healthy volunteers)
- Unable to undergo MRI scanning
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Initial assessment period
Participants undergo collection of clinical research data including imaging assessments to evaluate the aorta.
1 or more visits depending on participant group
Long-term Monitoring
Duration - Up to 5 years
Participants are monitored over time to observe progression of large artery stiffening, development of aortic aneurysm, and cardiac function.
Periodic visits over 5 years
Trial Site Locations
Total: 1 location
1
Christine Quast
Düsseldorf, Germany, 40225
Actively Recruiting
Loading map...
Research Team
C
Christine Quast, MD
L
Lisa Dannenberg, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here