Study of Aortic Wall Properties and Blood Flow in Healthy Adults and Patients with Aortic Stenosis or Aneurysms

What this Trial Is About

This research aims to understand the differences and regional characteristics of the aorta, the main artery that distributes blood throughout the body. It focuses on how the physical and mechanical properties of the aortic wall vary between regions and how these differences may cause problems like artery stiffening, which can lead to organ damage. The study follows a group of people, including healthy volunteers and patients with aortic conditions, to identify key factors in aortic disease. Participants include healthy volunteers, patients with severe aortic stenosis, and patients with aortic aneurysms. The study collects clinical data systematically over time to observe the progression of conditions affecting the aorta. The study is observational, with no treatments assigned, and focuses on gathering detailed information from participants to better understand aortic health and disease. During the study, researchers will track participants for up to five years, monitoring changes in large artery stiffness, development of aortic aneurysms, heart function measures such as diastolic dysfunction, and blood flow characteristics using MRI scans. Participants will undergo clinical assessments and imaging tests to provide data on their vascular health. This long-term observation aims to identify important changes in aortic conditions and their effects on the body.

Phenotyping Heterogeneity and Regionality of the Aorta