Actively Recruiting
Cardiometabolic Risk of Obese Subjects: Cross-sectional Study for the Identification of Genetic, Laboratory and Clinical Determinants
Led by IRCCS Azienda Ospedaliero-Universitaria di Bologna · Updated on 2024-12-05
240
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating cardiometabolic risk factors in people with obesity by studying genetic, clinical, and laboratory aspects. This observational study focuses on understanding how these factors contribute to cardiovascular risk in obese individuals. Participants are selected based on specific criteria including age and health status to better identify the underlying determinants of cardiometabolic risk. Participants will provide an additional blood sample during a dietetic visit for genetic and laboratory testing. Within one month of this visit, they will undergo a special non-invasive examination to assess vascular aging and artery health. This study does not involve any experimental treatments but collects detailed biological and clinical data to explore cardiometabolic risks. During the study, participants will have blood collected for genetic analyses, including gene sequencing and protein assays. They will also undergo vascular assessments to measure artery condition. Researchers will monitor various biomarkers such as miRNAs, insulinemia, C-peptide, and thyrotropin levels at baseline. The study is designed to gather comprehensive information about cardiovascular risk factors in obesity without affecting usual care.
CONDITIONS
Brief Title
Cardiometabolic Risk of Obese Subjects: Cross-sectional Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age greater than 18 years
- Body mass index (BMI) greater than 30 Kg/m2
- In primary prevention for cardiovascular disease
- Ability to communicate, understand, and follow study procedures
- Willingness to participate and provide informed consent
You will not qualify if you...
- Previously enrolled in this research by the involved units
- Glycated hemoglobin level above 55 mmol/L
- Obesity caused by endocrine diseases or medical treatments
- Heterozygous Familial Hypercholesterolemia (Dutch Lipid Score greater than 8)
- Hypercholesterolemia from lipid or extra-metabolic diseases
- Systemic inflammatory or cancerous diseases
- Active treatment with GLP-1 analogues
- Pregnancy or breastfeeding
- Any medical or surgical condition that hinders adherence to the study protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within 1 month after the dietetic visit
Participants undergo additional blood sample collection and non-invasive examinations to assess vascular aging and artery health.
1 study-specific visit (in-person)
Trial Site Locations
Total: 2 locations
1
Maria Letizia Petroni
Bologna, BO, Italy, 40138
Actively Recruiting
2
Azienda Ospedaliero-Universitaria "Renato Dulbecco" di Catanzaro
Catanzaro, Italy
Not Yet Recruiting
Research Team
M
Maria Letizia Petroni, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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