Actively Recruiting
Cardiovascular Risk Assessment For Kidney Transplantation Using Computed Tomography Coronary Angiography to Evaluate Patients Awaiting Transplant
Led by University of Edinburgh · Updated on 2026-02-13
332
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Edinburgh
Lead Sponsor
C
Chief Scientist Office of the Scottish Government
Collaborating Sponsor
AI-Summary
What this Trial Is About
Cardiovascular disease, such as heart attack, stroke, and heart failure, is the most common complication in people with kidney failure. Even after kidney transplantation, cardiovascular disease remains the leading cause of death. Current methods to assess cardiovascular risk before kidney transplantation do not effectively identify those at highest risk or improve outcomes. This research aims to develop a heart scan called computed tomography coronary angiography (CTCA) as a tool to better assess cardiovascular risk in patients waiting for a kidney transplant. Participants in this study will undergo a single CTCA scan before their kidney transplantation. This scan uses radiation to create detailed images of the heart’s arteries. The study focuses on patients who have been placed on the kidney transplant waiting list in Scotland. The goal is to see if CTCA can help predict which patients are at higher risk of cardiovascular problems after transplantation. During the study, researchers will follow participants for up to 60 months after the CTCA scan. They will track important outcomes like heart attacks, cardiovascular deaths, hospitalizations due to heart events, and overall survival. The study will also assess how well CTCA identifies patients at risk, helping improve risk management before and after kidney transplantation.
CONDITIONS
Brief Title
Cardiovascular Risk Assessment For Kidney Transplantation - Utility of Computed Tomography Coronary Angiography in the Assessment of Patients Awaiting Kidney Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Has kidney failure and is on the waitlist for a kidney transplant
- Age 16 years and over
- Able to give informed consent
You will not qualify if you...
- Contraindication to CT scanning, including contrast allergy
- Patients being considered for a simultaneous kidney-pancreas, kidney-liver and/or kidney-islet transplantation
- Inability to give informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single timepoint
Participants receive a single computed tomography coronary angiography (CTCA) scan to assess cardiovascular risk prior to kidney transplantation.
1 visit (in-person)
Duration - Up to 60 months
Participants are monitored for cardiovascular events and survival outcomes for up to 60 months following the CTCA scan.
Periodic follow-up visits as per routine care
Trial Site Locations
Total: 2 locations
1
Royal Infirmary of Edinburgh
Edinburgh, Lothian, United Kingdom, EH16 4SA
Actively Recruiting
2
Queen Elizabeth Hospital
Glasgow, United Kingdom, G51 4TF
Not Yet Recruiting
Research Team
G
Gavin B Chapman, MBChB
N
Neeraj Dhaun, MBChB
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here