Carotid Plaque Imaging Project (Identification of Vulnerable Atherosclerotic Plaques With Imaging and Biological Markers)

What this Trial Is About

This research aims to better understand atherosclerotic plaques, which can rupture or erode and lead to heart attacks and strokes. The study focuses on identifying vulnerable plaques (VP) that are prone to causing these events. Researchers are investigating plaque structure using imaging techniques, circulating markers, and the underlying disease mechanisms to find new ways to detect and possibly treat these dangerous plaques early. Participants in this observational study are patients undergoing carotid endarterectomy, a procedure to remove plaques from carotid arteries. The study involves detailed analysis of the removed plaques to reveal their structure and mechanisms. Researchers also use imaging methods and circulating markers to study plaque characteristics and work on developing new detection approaches. During the study, participants will be monitored for post-operative cardiovascular events through follow-up assessments planned for the years 2025, 2027, and 2029. The study tracks the occurrence of events since previous follow-ups to evaluate the risk associated with vulnerable plaques. Participation includes providing informed consent and undergoing standard surgical procedures with additional research assessments related to plaque analysis and imaging.

Carotid Plaque Imaging Project (CPIP)