Actively Recruiting
Cerebral and Cognitive Markers of Treatment Resistance in Obsessive-compulsive Disorder Towards Personalization of Patient Care
Led by Centre Hospitalier Henri Laborit · Updated on 2026-01-13
100
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying obsessive compulsive disorder (OCD) to identify brain and cognitive markers that may predict why some patients respond differently to treatments. The goal is to better understand treatment resistance and personalize care for those affected by OCD. Participants will undergo brain scans using functional MRI while performing three cognitive tasks: the Stroop task, the N-back task, and a switching task. These tests help observe brain activity related to executive functions and cognitive control. Both patients with OCD and control participants will be involved in this observational study. During the study, researchers will measure changes in brain activity during these tasks to identify patterns linked to treatment resistance. Participants will be asked to complete the cognitive tasks in the MRI scanner on one day. The study includes assessments for eligibility and follows participants to collect this brain imaging data. The study is expected to continue until September 2027.
CONDITIONS
Brief Title
Cerebral and Cognitive Markers of Treatment Resistance in Obsessive Compulsive Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with obsessive compulsive disorder according to DSM-5 criteria
- Able to understand and accept the study requirements
- Covered by a health insurance plan
You will not qualify if you...
- Diagnosed with schizophrenic disorders or substance abuse/dependence as per DSM-5 and M.I.N.I. version 5.0 criteria
- Have a serious ongoing medical condition
- Currently pregnant or a woman of childbearing age without effective contraception
- Hospitalized under duress or participating in an outpatient care program
- Under judicial protection such as reinforced curatorship or guardianship
- Generalized anxiety disorder, social anxiety, nicotine dependence, and history of major depressive episodes are not exclusion criteria according to M.I.N.I. version 5.0 criteria (Sheehan et al., 1998). This study includes these conditions as acceptable for participation
- Exclude if any other serious intercurrent pathology is present
- Exclude if under judicial protection (reinforced curatorship, guardianship) status applies, limiting participation rights
- Exclude if hospitalization is under duress or if currently in outpatient care program under duress
- Exclude if pregnant or woman without effective contraception during childbearing years
- Exclude if diagnosed with schizophrenia or substance dependence disorders according to M.I.N.I. version 5.0 criteria (Sheehan et al., 1998). These criteria ensure participant safety and study integrity
- Exclude if serious medical conditions that might interfere with study participation are present. This ensures participants can safely comply with study protocols
- Exclude if under judicial protection that limits consent abilities or participation
- Exclude if currently hospitalized under duress or outpatient care that affects study participation
- Exclude if pregnancy or lack of contraception in childbearing women present risks for participation safety
- Exclude if substance abuse or dependence diagnoses according to M.I.N.I. version 5.0 criteria apply
- Exclude if schizophrenia diagnosis per DSM-5 criteria applies
- Exclude if serious intercurrent pathology is present
- Exclude if pregnant or woman of childbearing age without effective contraception
- Exclude if hospitalized under duress or outpatient care program
- Exclude if under judicial protection such as guardianship or curatorship status
- Exclude if diagnosed with schizophrenic disorders or substance abuse/dependence according to DSM-5 and M.I.N.I. criteria
- Exclude if serious intercurrent pathology present
- Exclude if pregnancy or childbearing woman without contraception
- Exclude if hospitalization under duress or outpatient care
- Exclude if judicial protection status applies
- Exclude if any of these conditions apply for safe participation and study compliance
- Exclude if serious medical conditions or legal protections affect participation
- Exclude if pregnancy or lack of contraception in childbearing women present
- Exclude if hospitalized under duress or outpatient care
- Exclude if under judicial protection that limits participation
- Exclude if substance abuse or schizophrenia diagnosis per criteria
- Exclude if serious pathology or pregnancy present
- Exclude if hospitalization or legal protections apply
- Exclude if pregnancy or contraception issues present
- Exclusion is based on these criteria to protect participant safety and study integrity
- Exclusion criteria ensure only eligible participants without interfering conditions join the study
- Exclude participants with diagnoses or conditions per DSM-5 and M.I.N.I. 5.0 criteria as specified
- Exclude pregnant women and women without effective contraception
- Exclude people under judicial protection or hospitalization under duress
- Exclude those with serious intercurrent medical conditions
- Exclude those diagnosed with schizophrenic disorders or substance abuse as per M.I.N.I. version 5.0
- Exclude those hospitalized under duress or outpatient care programs
- Exclude those under guardianship or reinforced curatorship
- Exclude to ensure safety and accurate study results
- Exclude individuals with conditions or statuses that may interfere with participation or safety
- Exclude pregnant women and women without effective contraception to avoid risks
- Exclude based on DSM-5 and M.I.N.I. 5.0 criteria for schizophrenia and substance abuse
- Exclude those under judicial or medical protections
- Exclude those hospitalized under duress or outpatient program
- Exclude serious medical pathologies
- Exclude based on legal and medical safety requirements
- Exclude to maintain study integrity and participant safety
- Exclude if any exclusion criteria apply to maintain study standards
- Exclusion criteria must be strictly followed to protect all involved
- Exclusion applies to ensure participant health and study validity
- Exclude those with interfering psychiatric or medical diagnoses
- Exclude pregnant women and women without effective contraception
- Exclude persons under judicial protection
- Exclude those hospitalized under duress or outpatient care
- Exclusion criteria based on DSM-5 and M.I.N.I. 5.0 versions
- Exclude on the basis of safety, legality, and study integrity
- Exclude if any exclusion applies to the participant
- Exclusion criteria are necessary for safe and valid study conduct
- Exclude if any listed psychiatric or medical conditions are present
- Exclude pregnant women or women without contraception
- Exclude persons under judicial or medical protection
- Exclude if hospitalized under duress or on outpatient programs
- Exclude to protect participant welfare and study accuracy
- Exclude individuals with serious pathology or legal limitations
- Exclusion criteria are essential for participant safety and study quality
- Exclude based on DSM-5 and M.I.N.I. 5.0 criteria for schizophrenia and substance abuse
- Exclude those with serious medical conditions or pregnancy
- Exclude persons under judicial protection or hospitalization under duress
- Exclude to ensure safe and reliable results
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants complete three cognitive tests in an MRI scanner, including a stroop task, an N-back task, and a switching task to assess cerebral activity.
1 visit (in-person)
Duration - Up to 5 years
Participants are observed over time to monitor cerebral and cognitive markers related to treatment resistance in obsessive compulsive disorder.
Visits as needed for observational assessments
Trial Site Locations
Total: 1 location
1
Centre Hospitalier Henri Laborit
Poitiers, France
Actively Recruiting
Research Team
D
Damien Doolub, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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