What is this study trying to find out about obsessive compulsive disorder?

This study aims to identify brain and cognitive markers that help explain why some patients with obsessive compulsive disorder respond differently to treatments. Researchers want to use this information to personalize care. The study is led by Centre Hospitalier Henri Laborit and focuses on understanding treatment resistance.

Who may be eligible for this obsessive compulsive disorder clinical trial?

Adults aged 18 to 70 with a diagnosis of obsessive compulsive disorder according to DSM-5 criteria may be eligible. Participants must understand the study requirements and have health insurance. People with certain other psychiatric diagnoses or serious medical conditions may not qualify. Please review eligibility criteria for more details.

Is there any cost to participate in this obsessive compulsive disorder clinical trial?

Study-related care, including the brain scans and all study visits, is provided at no cost. However, personal travel expenses may vary and are not guaranteed to be covered. Participants should plan accordingly.

Actively Recruiting

Age: 18Years - 70Years

All Genders

Healthy Volunteers

ID05843604

Cerebral and Cognitive Markers of Treatment Resistance in Obsessive-Compulsive Disorder Towards Personalized Patient Care

Led by Centre Hospitalier Henri Laborit · Updated on 2026-01-13

100

Participants Needed

Research Sites

8 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are studying obsessive compulsive disorder OCD to identify brain and cognitive markers that may predict why some patients respond differently to treatments. The goal is to better understand treatment resistance and personalize care for those affected by OCD. Participants will undergo brain scans using functional MRI while performing three cognitive tasks the Stroop task, the N-back task, and a switching task. These tests help observe brain activity related to executive functions and cognitive control. Both patients with OCD and control participants will be involved in this observational study. During the study, researchers will measure changes in brain activity during these tasks to identify patterns linked to treatment resistance. Participants will be asked to complete the cognitive tasks in the MRI scanner on one day. The study includes assessments for eligibility and follows participants to collect this brain imaging data. The study is expected to continue until September 2027.

CONDITIONS

Brief Title

Cerebral and Cognitive Markers of Treatment Resistance in Obsessive Compulsive Disorder

Who Can Participate

Age: 18Years - 70Years

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Diagnosed with obsessive compulsive disorder according to DSM-5 criteria
Able to understand and accept the study requirements
Covered by a health insurance plan

You will not qualify if you...

Diagnosed with schizophrenic disorders or substance abuse/dependence as per DSM-5 and M.I.N.I. version 5.0 criteria
Have a serious ongoing medical condition
Currently pregnant or a woman of childbearing age without effective contraception
Hospitalized under duress or participating in an outpatient care program
Under judicial protection such as reinforced curatorship or guardianship
Generalized anxiety disorder, social anxiety, nicotine dependence, and history of major depressive episodes are not exclusion criteria according to M.I.N.I. version 5.0 criteria (Sheehan et al., 1998). This study includes these conditions as acceptable for participation
Exclude if any other serious intercurrent pathology is present
Exclude if under judicial protection (reinforced curatorship, guardianship) status applies, limiting participation rights
Exclude if hospitalization is under duress or if currently in outpatient care program under duress
Exclude if pregnant or woman without effective contraception during childbearing years
Exclude if diagnosed with schizophrenia or substance dependence disorders according to M.I.N.I. version 5.0 criteria (Sheehan et al., 1998). These criteria ensure participant safety and study integrity
Exclude if serious medical conditions that might interfere with study participation are present. This ensures participants can safely comply with study protocols
Exclude if under judicial protection that limits consent abilities or participation
Exclude if currently hospitalized under duress or outpatient care that affects study participation
Exclude if pregnancy or lack of contraception in childbearing women present risks for participation safety
Exclude if substance abuse or dependence diagnoses according to M.I.N.I. version 5.0 criteria apply
Exclude if schizophrenia diagnosis per DSM-5 criteria applies
Exclude if serious intercurrent pathology is present
Exclude if pregnant or woman of childbearing age without effective contraception
Exclude if hospitalized under duress or outpatient care program
Exclude if under judicial protection such as guardianship or curatorship status
Exclude if diagnosed with schizophrenic disorders or substance abuse/dependence according to DSM-5 and M.I.N.I. criteria
Exclude if serious intercurrent pathology present
Exclude if pregnancy or childbearing woman without contraception
Exclude if hospitalization under duress or outpatient care
Exclude if judicial protection status applies
Exclude if any of these conditions apply for safe participation and study compliance
Exclude if serious medical conditions or legal protections affect participation
Exclude if pregnancy or lack of contraception in childbearing women present
Exclude if hospitalized under duress or outpatient care
Exclude if under judicial protection that limits participation
Exclude if substance abuse or schizophrenia diagnosis per criteria
Exclude if serious pathology or pregnancy present
Exclude if hospitalization or legal protections apply
Exclude if pregnancy or contraception issues present
Exclusion is based on these criteria to protect participant safety and study integrity
Exclusion criteria ensure only eligible participants without interfering conditions join the study
Exclude participants with diagnoses or conditions per DSM-5 and M.I.N.I. 5.0 criteria as specified
Exclude pregnant women and women without effective contraception
Exclude people under judicial protection or hospitalization under duress
Exclude those with serious intercurrent medical conditions
Exclude those diagnosed with schizophrenic disorders or substance abuse as per M.I.N.I. version 5.0
Exclude those hospitalized under duress or outpatient care programs
Exclude those under guardianship or reinforced curatorship
Exclude to ensure safety and accurate study results
Exclude individuals with conditions or statuses that may interfere with participation or safety
Exclude pregnant women and women without effective contraception to avoid risks
Exclude based on DSM-5 and M.I.N.I. 5.0 criteria for schizophrenia and substance abuse
Exclude those under judicial or medical protections
Exclude those hospitalized under duress or outpatient program
Exclude serious medical pathologies
Exclude based on legal and medical safety requirements
Exclude to maintain study integrity and participant safety
Exclude if any exclusion criteria apply to maintain study standards
Exclusion criteria must be strictly followed to protect all involved
Exclusion applies to ensure participant health and study validity
Exclude those with interfering psychiatric or medical diagnoses
Exclude pregnant women and women without effective contraception
Exclude persons under judicial protection
Exclude those hospitalized under duress or outpatient care
Exclusion criteria based on DSM-5 and M.I.N.I. 5.0 versions
Exclude on the basis of safety, legality, and study integrity
Exclude if any exclusion applies to the participant
Exclusion criteria are necessary for safe and valid study conduct
Exclude if any listed psychiatric or medical conditions are present
Exclude pregnant women or women without contraception
Exclude persons under judicial or medical protection
Exclude if hospitalized under duress or on outpatient programs
Exclude to protect participant welfare and study accuracy
Exclude individuals with serious pathology or legal limitations
Exclusion criteria are essential for participant safety and study quality
Exclude based on DSM-5 and M.I.N.I. 5.0 criteria for schizophrenia and substance abuse
Exclude those with serious medical conditions or pregnancy
Exclude persons under judicial protection or hospitalization under duress
Exclude to ensure safe and reliable results

Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - 1 day

Participants complete three cognitive tests in an MRI scanner, including a stroop task, an N-back task, and a switching task to assess cerebral activity.

1 visit (in-person)

Long-term Monitoring

Duration - Up to 5 years

Participants are observed over time to monitor cerebral and cognitive markers related to treatment resistance in obsessive compulsive disorder.

Visits as needed for observational assessments

Research Team

Damien Doolub, MD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

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Frequently Asked Questions

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Cerebral and Cognitive Markers of Treatment Resistance in Obsessive-Compulsive Disorder Towards Personalized Patient Care

On this page

Sponsors

AI-Summary

What this Trial Is About

Brief Title

Who Can Participate

Eligibility Criteria

Your Study Journey

Research Team

How is the study designed?

Similar Trials

Study of a New 5-Day Accelerated rTMS Treatment for Depressi...

Studying Mental Health Development and Outcomes in Youth Age...

Studying Group Therapy Approaches to Reduce Symptoms of Obse...

Frequently Asked Questions

What is this study trying to find out about obsessive compulsive disorder?

Who may be eligible for this obsessive compulsive disorder clinical trial?

Is there any cost to participate in this obsessive compulsive disorder clinical trial?

What will I be asked to do in this obsessive compulsive disorder study?

What brain activity measurements are used in this study for obsessive compulsive disorder?

What happens after this obsessive compulsive disorder clinical trial ends?

Can I leave this obsessive compulsive disorder clinical trial if I change my mind?

Not the Right Trial for You?

On this page

Sponsors

Sponsors

Who Can Participate

Eligibility Criteria

Your Study Journey

How is the study designed?

Similar Trials

Study of a New 5-Day Accelerated rTMS Treatment for Depressi...

Studying Mental Health Development and Outcomes in Youth Age...

Studying Group Therapy Approaches to Reduce Symptoms of Obse...

Frequently Asked Questions

What is this study trying to find out about obsessive compulsive disorder?

Who may be eligible for this obsessive compulsive disorder clinical trial?

Is there any cost to participate in this obsessive compulsive disorder clinical trial?

What will I be asked to do in this obsessive compulsive disorder study?

What brain activity measurements are used in this study for obsessive compulsive disorder?

What happens after this obsessive compulsive disorder clinical trial ends?

Can I leave this obsessive compulsive disorder clinical trial if I change my mind?

Sponsors