Study of a New 5-Day Accelerated rTMS Treatment for Depression and OCD Using Targeted Brain Stimulation to Improve Symptoms and Identify Brain Biomarkers

What this Trial Is About

Researchers are evaluating an accelerated repetitive transcranial magnetic stimulation rTMS treatment for people with depression and obsessive-compulsive disorder OCD. This study aims to optimize rTMS to improve symptoms by testing a new 5-day accelerated protocol. Additionally, brain scans using functional magnetic resonance imaging fMRI will be used to identify brain markers that predict treatment response and help target the best brain areas for stimulation. Participants will be randomly assigned to receive rTMS targeting either the lateral prefrontal cortex LPFC or the dorsomedial prefrontal cortex DMPFC. They will undergo a 5-day treatment course with sessions delivered hourly for 10 hours each day. Those who partially respond may receive a second 5-day course, and non-responders may switch to receive treatment targeting the opposite brain area. The rTMS is delivered using the MagVenture MagPro System with Brainsight neuronavigation, providing 10 sessions daily of theta-burst stimulation lasting about ten minutes each. During the study, participants will have clinical assessments of their symptoms and fMRI brain scans before and after each treatment course to measure changes in symptom severity and brain connectivity. Researchers will track outcomes such as changes in depression and OCD rating scales at various time points depending on the number of treatment courses received. The study includes careful monitoring of treatment response and safety, with the total participation duration varying based on individual response and treatment needs.

Accelerated TMS for Depression and OCD