Changes in Body Fat and Liver Triglycerides in Adults with Non-Alcoholic Fatty Liver Disease After Bariatric Surgery or Lifestyle Intervention

What this Trial Is About

This research aims to understand changes in fat tissues, triglycerides in the liver and pancreas, and cholesterol levels after lifestyle changes or bariatric surgery in people with obesity and Non-Alcoholic Fatty Liver Disease NAFLD. It also tests whether brown fat, a special type of fat that produces heat, can serve as a marker for NAFLD development. The study includes people with mild to morbid obesity, some of whom may have metabolic syndrome or diabetes-related conditions. Participants are divided into four groups based on obesity severity and treatment choice morbidly obese patients undergoing bariatric surgery, morbidly obese patients choosing lifestyle intervention, mild to moderate obese patients randomized to lifestyle modification, or conventional care. Bariatric surgery involves standard procedures like gastric bypass or sleeve gastrectomy. The lifestyle program includes dietitian-led sessions focusing on diet and exercise over 12 months, with frequent consultations initially and monthly follow-ups thereafter. Participants undergo detailed assessments including MRI scans of fat tissues and organs at baseline, 4 months, and 12 months, plus blood tests measuring liver function, glucose, insulin resistance, and cholesterol. Physical measurements like weight, height, and waist circumference are recorded along with activity levels. The study measures the response of fat tissues using advanced MRI techniques and blood tests to evaluate treatment effects and the relationship between brown fat and NAFLD over one year.

Change of Adipose Tissues and Triglyceride After Bariatric Surgery or Life-style Intervention