Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population.
Lidia S Szczepaniak, Pamela Nurenberg, David Leonard...
https://pubmed.ncbi.nlm.nih.gov/15339742Actively Recruiting
Phase Not Applicable
Age: 18Years - 65Years
All Genders
ID03875625
Change of Adipose Tissues and Triglyceride in Obese Patients With Non-alcoholic Fatty Liver Disease After Bariatric Surgery or Life-style Intervention
Led by Chinese University of Hong Kong · Updated on 2025-02-13
80
Participants Needed
1
Research Sites
25 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to understand changes in fat tissues, triglycerides in the liver and pancreas, and cholesterol levels after lifestyle changes or bariatric surgery in people with obesity and Non-Alcoholic Fatty Liver Disease (NAFLD). It also tests whether brown fat, a special type of fat that produces heat, can serve as a marker for NAFLD development. The study includes people with mild to morbid obesity, some of whom may have metabolic syndrome or diabetes-related conditions. Participants are divided into four groups based on obesity severity and treatment choice: morbidly obese patients undergoing bariatric surgery, morbidly obese patients choosing lifestyle intervention, mild to moderate obese patients randomized to lifestyle modification, or conventional care. Bariatric surgery involves standard procedures like gastric bypass or sleeve gastrectomy. The lifestyle program includes dietitian-led sessions focusing on diet and exercise over 12 months, with frequent consultations initially and monthly follow-ups thereafter. Participants undergo detailed assessments including MRI scans of fat tissues and organs at baseline, 4 months, and 12 months, plus blood tests measuring liver function, glucose, insulin resistance, and cholesterol. Physical measurements like weight, height, and waist circumference are recorded along with activity levels. The study measures the response of fat tissues using advanced MRI techniques and blood tests to evaluate treatment effects and the relationship between brown fat and NAFLD over one year.
CONDITIONS
Brief Title
Change of Adipose Tissues and Triglyceride After Bariatric Surgery or Life-style Intervention
Who Can Participate
Age: 18Years - 65Years
All Genders
Eligibility Criteria
You may qualify if you...
- Body mass index (BMI) of 25 to 30 kg/m2
- BMI of 30 kg/m2 or higher with metabolic syndrome
- BMI of 35 kg/m2 or higher for morbid obesity
- Diagnosed with Non-Alcoholic Fatty Liver Disease
- Age between 18 and 65 years
You will not qualify if you...
- Other types of liver diseases
- Taking medications known to affect liver fat
- Waist circumference of 150 cm or more
- Weight of 250 kg or more
- Any condition that prevents safe MRI scanning (MRI contraindications)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - 12 months
Participants undergo either bariatric surgery or participate in a dietitian-led lifestyle modification program for 12 months. Those in the surgery group receive standard bariatric procedures. Participants in the lifestyle group attend weekly dietary consultation sessions for the first 4 months and monthly sessions for the following 8 months, including exercise consultations. Control group participants receive routine care with general advice on diet and exercise.
Weekly visits for the first 4 months, then monthly visits for the next 8 months for lifestyle group; surgical procedure and follow-up visits for surgery group; routine care visits for control group
Follow-up
Duration - 12 months
Participants attend metabolic assessment visits at 4 months and 12 months post-baseline including blood tests and MRI scans to monitor changes in adipose tissue and liver health.
3 visits (at baseline, 4 months, and 12 months) involving MRI scans and blood tests
Trial Site Locations
Total: 1 location
1
The Chinese University of Hong Kong, Prince of Wale Hospital
Hong Kong, Shatin, Hong Kong
Actively Recruiting
Loading map...
Research Team
W
Winnie C Chu, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Published Research Related To This Trial
Incidence of non-alcoholic fatty liver disease in Hong Kong: a population study with paired proton-magnetic resonance spectroscopy.
Vincent Wai-Sun Wong, Grace Lai-Hung Wong, David Ka-Wai Yeung...
https://pubmed.ncbi.nlm.nih.gov/25195550Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: a population study using proton-magnetic resonance spectroscopy and transient elastography.
Vincent Wai-Sun Wong, Winnie Chiu-Wing Chu, Grace Lai-Hung Wong...
https://pubmed.ncbi.nlm.nih.gov/21846782Metabolic and histological implications of intrahepatic triglyceride content in nonalcoholic fatty liver disease.
Fernando Bril, Diana Barb, Paola Portillo-Sanchez...
https://pubmed.ncbi.nlm.nih.gov/27981615Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects.
Kevin M Korenblat, Elisa Fabbrini, B Selma Mohammed...
https://pubmed.ncbi.nlm.nih.gov/18355813Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity.
Elisa Fabbrini, Faidon Magkos, B Selma Mohammed...
https://pubmed.ncbi.nlm.nih.gov/19706383Type 2 Diabetes Genetic Predisposition, Obesity, and All-Cause Mortality Risk in the U.S.: A Multiethnic Analysis.
Aaron Leong, Bianca Porneala, Josée Dupuis...
https://pubmed.ncbi.nlm.nih.gov/26884474Brown fat as a therapy for obesity and diabetes.
Aaron M Cypess, C Ronald Kahn
https://pubmed.ncbi.nlm.nih.gov/20160646The Relationship Between Brown Adipose Tissue Content in Supraclavicular Fat Depots and Insulin Sensitivity in Patients with Type 2 Diabetes Mellitus and Prediabetes.
Ekaterina Koksharova, Dmitry Ustyuzhanin, Yury Philippov...
https://pubmed.ncbi.nlm.nih.gov/28118051Visceral adiposity, insulin resistance and cancer risk.
Claire L Donohoe, Suzanne L Doyle, John V Reynolds
https://pubmed.ncbi.nlm.nih.gov/21696633