Actively Recruiting
Host-Microbiota Interactions Across the Gut Immune System: Characterization of Phenotype and Genotype of Early Onset Enteropathies
Led by Imagine Institute · Updated on 2025-04-30
1445
Participants Needed
12
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying early onset enteropathies, a condition affecting the intestines, by examining the genetic and phenotypic characteristics of patients who develop symptoms early in life. The goal is to understand the human pathways that help maintain intestinal balance despite the dense microbial environment in the lower intestine. This observational study collects biological samples to better characterize these conditions. Participants include patients with early onset enteropathies and their healthy relatives. Biological samples collected include blood from all participants, with some patients also providing saliva, skin and endoscopic biopsies, and feces. The study focuses on genetic analysis to increase the rate of genetic characterization of early onset enteropathies over a 40-year period. During the study, blood samples and other biological materials are collected from patients and their relatives. Researchers monitor genetic markers and phenotypes to improve understanding of the disease. The study involves long-term follow-up with a primary outcome of increasing genetic characterization rates. Participation involves biological sampling and data collection without treatment interventions.
CONDITIONS
Brief Title
Characterization of Phenotype and Genotype of Early Onset Enteropathies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Severe chronic enteropathy
- Patients developing first symptoms within the first 6 years of life, prioritizing those within the first 2 years
- Patients with later disease onset if there is a family history suggesting inherited mutations, especially in families with several affected members
- Relatives of patients, even if they have later onset enteropathy
You will not qualify if you...
- Participation in any treatment clinical study within 30 days before joining this study
- None other specified in the provided criteria text
- Note: Only this exclusion criterion is explicitly mentioned in the source data
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single timepoint
Participants provide biological samples such as blood, saliva, biopsies, and feces for genetic analysis.
1 visit (in-person)
Duration - Up to 40 years
Participants are monitored over time to observe genetic characteristics and disease progression.
Visits as needed for follow-up assessments
Trial Site Locations
Total: 12 locations
1
Centre Hospitalier Pellegrin-Enfants
Bordeaux, France, 33076
Actively Recruiting
2
Hôpital pédiatrique de Lyon
Bron, France, 69677
Actively Recruiting
3
Hôpital Jeanne de Flandre, CHRU de Lille
Lille, France, 59037
Actively Recruiting
4
Hôpital d'enfants de la Timone
Marseille, France, 13385
Actively Recruiting
5
Hôpital Saint Antoine
Paris, France, 75012
Actively Recruiting
6
Necker - Enfants Malades Hospital
Paris, France, 75015
Actively Recruiting
7
Hôpital Robert Debré
Paris, France, 75019
Actively Recruiting
8
Hôpital Trousseau
Paris, France, 75020
Actively Recruiting
9
Hôpital Sud
Rennes, France, 35203
Actively Recruiting
10
CHU Hautepierre
Strasbourg, France, 67000
Not Yet Recruiting
11
Hôpital des Enfants
Toulouse, France, 31059
Actively Recruiting
12
Hôpital Clocheville, CHU de Tours
Tours, France, 37000
Actively Recruiting
Research Team
N
Nadine Cerf-Bensussan
F
Fabienne Charbit-Henrion
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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