A screen for cognitive assessments for patients with vascular cognitive impairment no dementia.
Aihong Zhou, Jianping Jia
https://pubmed.ncbi.nlm.nih.gov/19347838Actively Recruiting
Age: 18Years +
All Genders
Healthy Volunteers
ID03653156
China Cognition and Aging Study: a Multi-center, National-wide, Longitudinal Study in China
Led by Capital Medical University · Updated on 2026-03-23
100000
Participants Needed
65
Research Sites
N/A
Total Duration
On this page
Sponsors
C
Capital Medical University
Lead Sponsor
B
Beijing Tiantan Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are conducting the China Cognition and Aging Study (China COAST) to understand dementia and its subtypes in China, including mild cognitive impairment (MCI), sporadic and familial Alzheimer's disease (SAD and FAD), vascular dementia (VaD), and other types. This large, national, multi-center, longitudinal observational study aims to build a comprehensive database to improve diagnosis, study the causes and genetic features, monitor disease progression, and evaluate prevention and treatment strategies, including non-drug interventions. The study also focuses on education, stigma, and management of dementia in the Chinese population. Participants include individuals with MCI, SAD, FAD, VaD, normal cognitive function, and other dementias recruited from both community and hospital populations. Researchers collect detailed demographic, clinical, genetic, imaging, and biological sample data. Study procedures include clinical evaluations, neuropsychological tests, imaging such as PET/MR scans, and fluid biomarker analysis. The study follows participants through repeated assessments every 2 to 3 years, tracking changes from normal cognition to MCI and dementia, and exploring risk and protective factors. Participants engage in baseline and follow-up visits involving cognitive and mental health assessments using standardized scales like MMSE, MoCA, and CDR. Genetic analyses and biomarker measurements support diagnosis and disease understanding. The study also conducts randomized controlled trials of non-pharmacological treatments and education programs aimed at improving dementia awareness and care. Safety monitoring and informed consent are carefully managed, with ongoing follow-up to track disease progression and effects of interventions over time.
CONDITIONS
Brief Title
China Cognition and Aging Study
Who Can Participate
Age: 18Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Community participants aged 55 years or older who consent to join the study
- Hospital participants aged 18 years or older evaluated for cognitive function
- Diagnosis of MCI according to 2004 Peterson's criteria with CDR = 0.5 and memory loss
- Diagnosis of sporadic Alzheimer's disease meeting DSM-IV-R and NINCDS-ADRDA or NIA-AA criteria
- Members of familial Alzheimer's disease families aged 18 or older with reliable informants
- Diagnosis of probable vascular dementia per NINDS-AIREN criteria with MRI assessment
- Normal control individuals aged 18 or older with normal MMSE and MoCA scores as defined by education level
You will not qualify if you...
- History of stroke with significant cerebral small vessel disease or neurological focal signs
- Neurological diseases causing brain dysfunction such as depression, brain tumor, Parkinson's disease, epilepsy, encephalitis, multiple sclerosis, brain trauma, normal intracranial pressure hydrocephalus
- Systemic diseases causing cognitive impairment including liver, renal, thyroid insufficiency, severe anemia, vitamin deficiencies, syphilis, HIV infection, alcohol or drug abuse
- Mental or neurodevelopmental retardation
- Contraindications to MRI
- Diseases preventing cognitive examination
- Refusal to provide blood samples or refusal to sign informed consent
- Family history of dementia in sporadic Alzheimer's disease group
- Dementia caused by other factors or other types of dementia in familial Alzheimer's disease group
- Severe circulatory, respiratory, urinary, digestive, or hematopoietic diseases and cancer in familial Alzheimer's disease group
- Pregnant or lactating women in familial Alzheimer's disease group
- No reliable informants in familial Alzheimer's disease group
- History of mental illness or congenital mental retardation in vascular dementia group
- Abnormal MMSE or MoCA scores in normal control group
- History of cerebral infarction or traumatic brain injury or related MRI findings in normal control group
- Presence of other non-Alzheimer degenerative dementias such as frontotemporal dementia, dementia with Lewy bodies, Parkinson's disease dementia, corticobasal degeneration, and others mentioned in exclusions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Baseline assessment
Participants undergo assessments including cognitive function tests, genetic testing, MRI scans, and biofluid sample collection to determine cognitive status and subtype classification.
1 baseline visit (in-person)
Long-term Monitoring
Duration - Up to 20 years
Participants are followed up every 2 to 3 years to monitor cognitive changes, biomarker levels, and disease progression through repeated evaluations and sample collections.
Follow-up visits every 2 to 3 years
Trial Site Locations
Total: 65 locations
1
The First Affiliated Hospital of Anhui Medical University
Hefei, Anhui, China
Actively Recruiting
2
Beijing Geriatric Hospital
Changping, Beijing Municipality, China
Actively Recruiting
3
Beijing Chao Yang Hospital
Chaoyang, Beijing Municipality, China
Actively Recruiting
4
China-Japan Friendship Hospital
Chaoyang, Beijing Municipality, China
Actively Recruiting
5
Dongfang Hospital Affiliated to Beijing University of Chinese Medicine
Fengtai, Beijing Municipality, China
Actively Recruiting
6
Chinese PLA General Hospital
Haidian, Beijing Municipality, China
Actively Recruiting
7
Fu Xing Hospital, Capital Medical University
Haidian, Beijing Municipality, China
Actively Recruiting
8
Peking University Third Hospital
Haidian, Beijing Municipality, China
Actively Recruiting
9
Peking Union Medical College Hospital
Xicheng, Beijing Municipality, China
Actively Recruiting
10
Peking University First Hospital
Xicheng, Beijing Municipality, China
Actively Recruiting
11
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Yuzhong, Chongqing Municipality, China
Actively Recruiting
12
The Second Affiliated Hospital of Chongqing Medical University
Yuzhong, Chongqing Municipality, China
Actively Recruiting
13
Fujian Medical University Union Hospital
Fujian, Guangdong, China
Actively Recruiting
14
Guangzhou Psychiatric Hospital
Guangzhou, Guangdong, China
Actively Recruiting
15
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Zhongshan, Guangdong, China
Actively Recruiting
16
First Affiliated Hospital of Guangxi Medical University
Nanning, Guangxi, China
Actively Recruiting
17
The Affiliated Hospital Of Guizhou Medical University
Guiyang, Guizhou, China
Actively Recruiting
18
Handan Central Hospital
Handan, Hebei, China
Actively Recruiting
19
First Hospital of Shijiazhuang City
Shijiazhuang, Hebei, China
Actively Recruiting
20
Tangshan Worker's Hospital
Tangshan, Hebei, China
Actively Recruiting
21
Hebei General Hospital
Zhijiazhuang, Hebei, China
Actively Recruiting
22
First Affiliated Hospital of Harbin Medical University
Haerbin, Heilongjiang, China
Actively Recruiting
23
Kaifeng Central Hospital
Kaifeng, Henan, China
Actively Recruiting
24
Henan Provincial People's Hospital
Zhengzhou, Henan, China
Actively Recruiting
25
People's Hospital of Zhengzhou
Zhengzhou, Henan, China
Actively Recruiting
26
People's Hospital Affiliated Hubei Medical University
Wuhan, Hubei, China
Actively Recruiting
27
Tongji Hospital
Wuhan, Hubei, China
Actively Recruiting
28
The Third Xiangya Hospital of Central South University
Wuhan, Hunan, China
Actively Recruiting
29
Wuhan University Zhongnan Hospital
Wuhan, Hunan, China
Actively Recruiting
30
Xiangya Hospital of Central South University
Wuhan, Hunan, China
Actively Recruiting
31
Nantong University Affiliated Hospital
Nantong, Jiangsu, China
Actively Recruiting
32
Subei People's Hospital of Jiangsu
Subei, Jiangsu, China
Actively Recruiting
33
Mineral General Hospital, Xuzhou
Xuzhou, Jiangsu, China
Actively Recruiting
34
Jiangxi Provincial People's Hospital
Nanchang, Jiangxi, China
Actively Recruiting
35
China-Japan friendship Hospital of Jilin university
Changchun, Jilin, China
Actively Recruiting
36
The First Hospital of Jilin University
Changchun, Jilin, China
Actively Recruiting
37
Changda Hospital, Anshan
Anshan, Liaoning, China
Actively Recruiting
38
Affiliated Zhongshan hospital of Dalian university
Dalian, Liaoning, China
Actively Recruiting
39
The First Affiliated Hospital of Dalian Medical University
Dalian, Liaoning, China
Actively Recruiting
40
First Hospital of China Medical University
Shenyang, Liaoning, China
Actively Recruiting
41
Baotou Central Hospital
Baotou, Nei Monggol, China
Actively Recruiting
42
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, China
Actively Recruiting
43
The People's Hospital of Ningxia
Yinchuan, Ningxia, China
Actively Recruiting
44
Qilu Hospital of Shandong University
Jinan, Shandong, China
Actively Recruiting
45
Shandong Provincial Hospital
Jining, Shandong, China
Actively Recruiting
46
Qilu Hospital of Shandong University (Qingdao)
Qingdao, Shandong, China
Actively Recruiting
47
QingDao Municipal Hospital
Qingdao, Shandong, China
Actively Recruiting
48
The Affiliated Hospital of Qingdao University
Qingdao, Shandong, China
Actively Recruiting
49
The 88th Hospital of PLA
Tai’an, Shandong, China
Actively Recruiting
50
Shanghai Changzheng Hospital
Huangpu, Shanghai Municipality, China
Actively Recruiting
51
Ruijin Hospital
Luwan, Shanghai Municipality, China
Actively Recruiting
52
RenJi Hospital
Putong, Shanghai Municipality, China
Actively Recruiting
53
The First Affiliated Hospital of Shanxi Medical University
Taiyuan, Shanxi, China
Actively Recruiting
54
First Affiliated Hospital Xi'an Jiaotong University
Xi’an, Shanxi, China
Actively Recruiting
55
Tang-Du Hospital
Xi’an, Shanxi, China
Actively Recruiting
56
Affiliated Hospital of North Sichuan Medical College
Nanchong, Sichuan, China
Actively Recruiting
57
Zigong First People's Hospital
Zigong, Sichuan, China
Actively Recruiting
58
Tianjin Huanhu Hospital
Xianshuigu, Tianjin Municipality, China
Actively Recruiting
59
Tianjin Medical University General Hospital
Xiaobailou, Tianjin Municipality, China
Actively Recruiting
60
Traditional Chinese Medicine Hospital of Xinjiang Autonomous Region
Ürümqi, Xinjiang, China
Actively Recruiting
61
First Affiliated Hospital of Zhejiang University
Hangzhou, Zhejiang, China
Actively Recruiting
62
Shao Yifu Hospital of Zhejiang Medical University
Hangzhou, Zhejiang, China
Actively Recruiting
63
Zhejiang Provincial People's Hospital
Hangzhou, Zhejiang, China
Actively Recruiting
64
Ningbo City Medical Treatment Center Lihuili Hospital
Ningbo, Zhejiang, China
Actively Recruiting
65
First Affiliated Hospital of Wenzhou Medical Univeristy
Wenzhou, Zhejiang, China
Actively Recruiting
Loading map...
Research Team
J
Jianping Jia, Doctor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Published Research Related To This Trial
Different cognitive profiles between mild cognitive impairment due to cerebral small vessel disease and mild cognitive impairment of Alzheimer's disease origin.
Aihong Zhou, Jianping Jia
https://pubmed.ncbi.nlm.nih.gov/19891819Mapping the altered patterns of cerebellar resting-state function in longitudinal amnestic mild cognitive impairment patients.
Feng Bai, Wei Liao, David R Watson...
https://pubmed.ncbi.nlm.nih.gov/20930266Frequency-dependent changes in the amplitude of low-frequency fluctuations in amnestic mild cognitive impairment: a resting-state fMRI study.
Ying Han, Jinhui Wang, Zhilian Zhao...
https://pubmed.ncbi.nlm.nih.gov/21118724Montreal cognitive assessment in detecting cognitive impairment in Chinese elderly individuals: a population-based study.
Jihui Lu, Dan Li, Fang Li...
https://pubmed.ncbi.nlm.nih.gov/22228824Neurology and neurologic practice in China.
Fu-Dong Shi, Jian-Ping Jia
https://pubmed.ncbi.nlm.nih.gov/22123780Combination of plasma biomarkers and clinical data for the detection of sporadic Alzheimer's disease.
Yangtong Han, Jianping Jia, Xiang-Fei Jia...
https://pubmed.ncbi.nlm.nih.gov/22503901The Informant Questionnaire on Cognitive Decline in the Elderly individuals in screening mild cognitive impairment with or without functional impairment.
Fang Li, Xiang-Fei Jia, Jianping Jia
https://pubmed.ncbi.nlm.nih.gov/23172761G1/S checkpoint proteins in peripheral blood lymphocytes are potentially diagnostic biomarkers for Alzheimer's disease.
Juexian Song, Shuying Wang, Mengshan Tan...
https://pubmed.ncbi.nlm.nih.gov/22922216Combination of p53(ser15) and p21/p21(thr145) in peripheral blood lymphocytes as potential Alzheimer's disease biomarkers.
Mengshan Tan, Shuying Wang, Juexian Song...
https://pubmed.ncbi.nlm.nih.gov/22503900