China Registry Study on Inherited Ventricular Arrhythmias Including Brugada, Long QT, Short QT, Early Repolarization, and Catecholaminergic Polymorphic VT Syndromes

What this Trial Is About

This research aims to build a risk stratification system for malignant inherited ventricular arrhythmias, including Brugada syndrome, Long QT syndrome, Short QT syndrome, Early repolarization syndrome, and Catecholaminergic polymorphic ventricular tachycardia. It is a prospective, observational, multi-center registry involving 500 participants recruited from 10 centers across China. The study focuses on exploring the relationship between genetic factors and clinical features to improve diagnosis and risk assessment of these inherited heart rhythm conditions. Participants diagnosed with one of the specified inherited ventricular arrhythmias will be enrolled and followed every 6 months. Clinical data such as medical history, laboratory tests, imaging, medications, and procedures will be collected from medical records. Blood samples will also be taken to analyze genes and other biological markers that might help identify risk indicators for these conditions. Throughout the study, participants will be interviewed and assessed regularly to monitor their arrhythmia status, medication use, and any clinical events. The primary outcome measured is the occurrence of sustained tachycardia, ventricular fibrillation, or sudden cardiac death over five years. Secondary outcomes include episodes of arrhythmia and all-cause mortality. This long-term follow-up aims to gather comprehensive data to better understand and manage malignant inherited ventricular arrhythmias.

China Inherited Ventricular Arrhythmias Registry