Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

What this Trial Is About

Researchers are investigating ways to prevent type 2 diabetes in teenage girls who are at risk, particularly focusing on those with elevated depression symptoms. The study compares cognitive-behavioral therapy (CBT), exercise training, and combinations of these treatments to see if they can reduce stress, improve mood, increase physical activity and fitness, and decrease insulin resistance. This is important because adolescent-onset type 2 diabetes can progress more aggressively, and depression can worsen insulin resistance and reduce exercise adherence. The study includes four groups of adolescent females aged 12 to 17 at risk for type 2 diabetes with elevated depression. Each group will participate in 6-week sessions of CBT or exercise training, either alone or followed by the other intervention for another 6 weeks, totaling 12 weeks. Each session lasts 1 hour per week, and participants are assigned home practice throughout the intervention period. Participants will attend weekly group sessions and be assessed over a 1-year period. Researchers will measure insulin resistance, insulin sensitivity, fitness levels, exercise enjoyment and self-efficacy, depression symptoms, eating behaviors, sleep quality, body mass index, and adiposity. These evaluations help understand how the treatments affect depression, physical activity, and diabetes risk. The study is randomized and single-blind, with ongoing monitoring and follow-up to evaluate long-term outcomes.

Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes