Actively Recruiting
A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression
Led by Juliana Zambrano, MD, MPH · Updated on 2025-07-28
10
Participants Needed
1
Research Sites
49 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a pilot clinical trial to assess the feasibility, safety, and preliminary efficacy of ketamine-assisted group therapy for Spanish-speaking adults with depression
CONDITIONS
Official Title
A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Self-identifying Latinx, Spanish-speaking
- Adults aged 18 to 64 years
- Meet DSM-5 criteria for major depressive disorder as evaluated by study clinician
- Montgomery-Asberg depression scale (MADRS) score of 20 or above at baseline
- Must have an MGB psychiatrist and primary care provider
You will not qualify if you...
- History of primary psychotic disorder
- History of Bipolar I disorder
- Unstable complex PTSD as assessed by study clinician
- History of dissociative identity disorder
- History of neurocognitive disorder
- History of severe or recent substance use disorder
- Uncontrolled hypertension, tachycardia, or unstable cardiopulmonary disease
- Blood pressure on initial screen must be below 140/90 mmHg
- History of aortic dissection
- History of myocardial infarction
- History of aneurysm
- History of hepatic impairment
- History of epilepsy
- History of prior hypersensitivity to ketamine
- Body Mass Index greater than 35
- Body Mass Index less than 18.5
- Pregnant, breastfeeding, or planning pregnancy within 12 weeks of treatment completion
- Enrolled in other clinical trial for depression or behavioral health
- Inability to provide consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital, Chelsea
Chelsea, Massachusetts, United States, 02114
Actively Recruiting
Research Team
J
Juliana Zambrano, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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