Cognitive and Immune Changes in Adults With Smell Loss and Chronic Rhinosinusitis Following Smell Training

What this Trial Is About

This research study focuses on adults experiencing smell loss, particularly those with chronic rhinosinusitis CRS with nasal polyps, as well as healthy control participants. The study aims to evaluate baseline olfactory function, mental health status, clinical severity, and immune system profiles. The goal is to identify molecules related to smell loss by analyzing tissue and blood samples, which may guide the development of future treatments and explore connections with cognitive function. Participants include adults with CRS with nasal polyps who have lost their sense of smell, as well as control groups without smell loss or CRS. Some participants with smell loss will undergo a 3-month smell training program to assess its impact on their olfactory function, immune changes, and mental health. Control participants will only have baseline testing without follow-up assessments. Throughout the study, participants will undergo evaluations at the beginning and after three months, including smell tests, quality-of-life questionnaires related to smell loss, cognitive assessments, and measurements of nasal cytokine levels. The research team will monitor changes in these areas to understand the effects of smell training and the underlying biological factors. The study will last approximately three months, with some participants having follow-up assessments after the training period.

Cognitive and Immunologic Profiles of Patients With Olfactory Dysfunction After Smell Training