Actively Recruiting
Led by Beijing Anzhen Hospital · Updated on 2026-01-21
200
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are evaluating how Continuous Positive Airway Pressure (CPAP) treatment affects blood pressure in adults aged 18 to 70 who have obstructive sleep apnea (OSA) and high or uncontrolled blood pressure. The study aims to find out which patients benefit the most in blood pressure reduction from CPAP and whether adding a sleep aid medication can improve CPAP effectiveness for those who experience insomnia or frequent awakenings at night. This observational study is sponsored by Beijing Anzhen Hospital and focuses on blood pressure control and sleep quality in OSA patients. Participants will use an auto-titrating CPAP device for at least 4 hours each night and at least 21 nights per month over about 3 months, with fitted masks and support to encourage use. Those with difficulty sleeping may also choose to take a short course of sleep aid medication (trazodone or zopiclone) for 4 weeks. The study forms natural sub-groups based on these interventions: CPAP only, CPAP plus trazodone, CPAP plus zopiclone, or drug only for those who decline CPAP. During the study, participants will undergo full-night sleep monitoring and 24-hour blood pressure monitoring to tailor CPAP pressure. Researchers will use questionnaires, actigraphy wristwatches, and additional sleep studies to observe changes in sleep and blood pressure. Blood and urine samples will be collected for safety checks. Participants are free to withdraw anytime without penalty, and study-related care including devices, medications, and tests are provided at no cost. The primary outcome measured is blood pressure after 3 months of CPAP treatment.
CONDITIONS
A Cohort Study on Increasing Blood Pressure Benefits in Sleep Apnea Patients After CPAP Treatment
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 3 months
Participants undergo auto-titrating continuous positive airway pressure (CPAP) treatment for 3 months with mask-fitting, education, and side-effect management to maximize adherence. Some participants may receive additional 4-week bedtime medication at physician discretion.
Regular visits for mask-fitting, education, and side-effect management during treatment
Duration - Post 3 months of CPAP treatment
Participants are observed for changes in blood pressure and sleep quality after completing CPAP treatment.
1 to 2 visits depending on assessments
Total: 1 location
1
Anzhen Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 100069
Actively Recruiting
J
Jiang Xie, M.D.
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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