Randomized Study Comparing Eleveld and Schnider Models for Propofol Anesthesia During Spinal Surgery in Adults

What this Trial Is About

Researchers are evaluating two different target-controlled infusion models, the Schnider and Eleveld models, to compare their effects on anesthetic depth and blood pressure responses during the first 10 minutes of anesthesia induction in adults undergoing spinal surgery. The study focuses on how these models influence hemodynamic stability and anesthetic depth during this critical early period. Participants will be randomly assigned to receive propofol via either the Schnider or Eleveld pharmacokineticpharmacodynamic model using a target-controlled infusion system. All patients will also receive fentanyl and rocuronium as part of a standardized anesthesia induction protocol. Standard monitoring including heart rate, invasive blood pressure, electrocardiography, oxygen saturation, and bispectral index will be used before and during the first 10 minutes after induction to capture hemodynamic and anesthetic depth changes. Throughout the study, vital signs and bispectral index values will be recorded at baseline and at 1, 3, 5, and 10 minutes post-induction. Additional measures include time to bispectral index below 40, burst suppression duration, total propofol dose in the first 5 minutes, need for extra propofol, vasopressor use, heart rate and blood pressure responses to intubation, and use of esmolol. The total duration of participation covers the anesthesia induction and immediate monitoring during surgery.

Comparison of Hemodynamic Responses During Anesthesia Induction Using Eleveld and Schnider