Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure (CASA RELAX) Using Desirability of Outcome Ranking (DOOR) and Response Adjusted for Duration of Antibiotic Risk (RADAR) - A Randomized Controlled Trial

What this Trial Is About

Researchers are evaluating the safety, effectiveness, and practicality of shorter courses of antibiotics after surgery for simple and complicated appendicitis. This study aims to see if reducing antibiotic use can lower the chance of side effects while still keeping patients safe after their appendectomy. The trial is a randomized controlled study conducted at a single center. Participants are assigned to one of two groups based on their type of appendicitis and post-operative antibiotic treatment. Those in the restrictive group with simple appendicitis receive no post-operative antibiotics, while those with complicated appendicitis receive up to 24 hours of antibiotics. In the liberal group, participants with simple appendicitis receive 24 hours of antibiotics, and those with complicated appendicitis receive up to 4 days of antibiotics. Treatments use standard antibiotics chosen by physicians. During the study, participants will be monitored for up to 30 days after surgery to track any infections or antibiotic-related complications, as well as any deaths. Researchers will assess safety by reviewing these outcomes and gather follow-up information through phone contact. The total involvement includes post-surgery monitoring to evaluate the impact of different antibiotic durations on recovery and adverse events.

Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure - UCSF