Management of Acute Pain After Thoracic Combat Trauma Using Cryoablation or Radiofrequency Ablation A Multicenter Study in Ukraine

What this Trial Is About

Researchers are evaluating two minimally invasive procedures, cryoablation and radiofrequency ablation, for managing acute pain following thoracic injuries sustained during combat. This multicenter clinical trial in Ukraine aims to compare the effectiveness and safety of these treatments in reducing severe chest pain and improving recovery. Both methods target intercostal nerves responsible for pain transmission, with the goal of reducing pain intensity, opioid use, and improving respiratory function and quality of life. Participants will be randomly assigned to receive either cryoablation or radiofrequency ablation, performed using percutaneous, image-guided techniques. Cryoablation applies extreme cold to temporarily interrupt nerve conduction, while radiofrequency ablation uses controlled heat to modulate nerve function. The number of intercostal levels treated depends on the injury pattern, and both procedures are delivered alongside standard trauma care. Assessments occur before and after the procedures to measure pain relief and functional improvements. During the study, participants will have pain intensity measured at 4, 24, and 72 hours post-procedure using a verbal numeric rating scale. Researchers will also monitor opioid medication use, mechanical pain sensitivity via Von Frey testing, and pulmonary function through incentive spirometry. Quality of life and emotional well-being will be assessed with validated tools including the LANS scale, McGill Pain Questionnaire, and PHQ-9 depression screening. Safety monitoring will focus on immediate and early complications. The study spans acute treatment and follow-up periods to support improved pain management decisions in this patient group.

Comprehensive Multicenter Study on the Management of Acute Pain Following Thoracic Combat-Related Trauma in Ukraine