Comparing Survival After Two Types of Bystander CPR in Out-of-Hospital Cardiac Arrest Chest Compression Only CPR Versus Standard CPR With Rescue Breaths A Randomized Study of Trained Bystanders

What this Trial Is About

Out-of-hospital cardiac arrest OHCA is a leading cause of death in industrialized countries. This trial investigates whether chest compression only CPR CO-CPR is no worse than standard CPR S-CPR in improving survival when performed by bystanders trained in CPR during witnessed, non-asphyxic OHCA events. The study also explores if CO-CPR may increase survival rates compared to S-CPR. Participants are randomly assigned to receive dispatcher instructions for either CO-CPR, which involves continuous chest compressions without rescue breaths, or S-CPR, which includes chest compressions and rescue breaths in a 302 ratio. The trial is conducted nationally in Sweden with expansion planned in northern Italy and includes a run-in phase, pilot study, and a main study focused on 30-day survival. During the study, emergency dispatchers provide instructions to bystanders at the scene. Researchers collect data on survival at 1 day, 30 days, and 1 year, as well as neurological outcomes at discharge. The main outcome is survival 30 days after the cardiac arrest. This trial monitors real-life emergency situations to assess the effectiveness of these CPR methods in improving survival.

Compression Only CPR Versus Standard CPR in Out-Of-Hospital Cardiac Arrest - A Randomized Survival Study