Actively Recruiting
A Randomized Trial Comparing Survival After a Simplified Form of Cardiopulmonary Resuscitation (Compressions Only) Versus Standard CPR With Compressions and Rescue Breaths
Led by Karolinska Institutet · Updated on 2026-05-08
3260
Participants Needed
2
Research Sites
52 weeks
Total Duration
On this page
Sponsors
K
Karolinska Institutet
Lead Sponsor
S
Swedish Heart Lung Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Out-of-hospital cardiac arrest (OHCA) is a leading cause of death in industrialized countries. This trial investigates whether chest compression only CPR (CO-CPR) is no worse than standard CPR (S-CPR) in improving survival when performed by bystanders trained in CPR during witnessed, non-asphyxic OHCA events. The study also explores if CO-CPR may increase survival rates compared to S-CPR. Participants are randomly assigned to receive dispatcher instructions for either CO-CPR, which involves continuous chest compressions without rescue breaths, or S-CPR, which includes chest compressions and rescue breaths in a 30:2 ratio. The trial is conducted nationally in Sweden with expansion planned in northern Italy and includes a run-in phase, pilot study, and a main study focused on 30-day survival. During the study, emergency dispatchers provide instructions to bystanders at the scene. Researchers collect data on survival at 1 day, 30 days, and 1 year, as well as neurological outcomes at discharge. The main outcome is survival 30 days after the cardiac arrest. This trial monitors real-life emergency situations to assess the effectiveness of these CPR methods in improving survival.
CONDITIONS
Brief Title
Compression Only CPR Versus Standard CPR in Out-Of-Hospital Cardiac Arrest - A Randomized Survival Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Unconsciousness with no, abnormal, or agonal breathing (suspected out-of-hospital cardiac arrest)
- The cardiac arrest event is witnessed (seen or heard)
- Any bystander present has previous CPR training
- Adults aged 18 years or older
You will not qualify if you...
- Age below 18 years
- Cardiac arrest collapse is not witnessed
- Bystander has no prior CPR training
- Obvious asphyxia such as hanging, foreign body obstruction, suffocation, or strangulation
- Obvious drug overdose or intoxication
- Pregnancy
- Trauma including penetrating, blunt, or burn injuries
- Cases not verified as cardiac arrest by emergency medical services
- Previous do not resuscitate (DNR) decision
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Screening and enrollment occur together at the dispatch center when a cardiac arrest is witnessed and CPR instructions are given.
Duration - Until emergency medical services arrive or resuscitation ends
Participants receive instructions from a dispatcher to perform either chest compression only CPR or standard CPR including rescue breaths.
Intervention occurs at the time of the cardiac arrest event; no scheduled visits.
Duration - 30 days
Participants are monitored for survival and neurological outcomes up to 30 days after the cardiac arrest event.
Follow-up assessments occur up to 30 days post-event to evaluate survival and neurological status.
Trial Site Locations
Total: 2 locations
1
AREU, Agenzia Regionale Emergenza Urgenza
Bergamo, Italy
Actively Recruiting
2
SOS Alarm AB
Stockholm, Sweden
Actively Recruiting
Research Team
J
Jacob Hollenberg, MD. PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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