Canker Sore (Aphthous Ulcer)

This research aims to evaluate how full-arch implant-supported prostheses affect lip support in patients undergoing complex dental rehabilitation. The study focuses on how different clinical and laboratory decisions between diagnosis and prosthesis delivery may influence the prosthetic design and the patient's facial profile. Advanced 3D facial scanning and superimposition techniques allow precise measurement of vertical occlusion and lip support. Participants will undergo removal of their full-arch implant-supported prostheses, with digital facial images captured before and after this procedure using a facial scanner. This observational study leverages modern digital technology to measure changes objectively and does not involve experimental treatments. During the study, researchers will assess changes in the volume around the mouth area, distances between the lips and esthetic lines on the facial profile, and angles related to the nose and lips. These measurements occur on the same day as the prosthesis removal. The study helps improve understanding of facial changes related to dental prostheses and involves participants collaborating with the research protocol through imaging and clinical assessments.

Researchers are evaluating noninvasive imaging methods to study the appearance of skin and mucosal lesions to improve diagnostic accuracy before a biopsy is needed and to help guide treatment planning. This study involves creating an Image Repository to store these images for clinical practice, teaching, training, and future research. It uses a high-resolution Optical Coherence Tomography (OCT) device called ApolloVueae S100 Image System that provides detailed cross-sectional and en-face images with cellular information. Participants with muco-cutaneous lesions, including normal skin, benign lesions, or neoplastic conditions, identified during routine clinical care will undergo various non-invasive imaging tests. These include dermoscopic imaging, 3-dimensional total body photography, confocal microscopy, OCT imaging, ultrasound, hyperspectral imaging, electrical impedance spectroscopy, and patient self-imaging using mobile phone technology with dermatoscope attachments. Images will be collected of untreated and treated lesions over a period of 7 years. Participants will have their lesions imaged using these non-invasive tools, with images collected and stored in the Image Repository. Assessments include capturing detailed images using specialized devices to evaluate lesion morphology, depth, vascular features, and biochemical information. Researchers will monitor the imaging data to support clinical decisions, teaching, and future research. Participation may involve multiple imaging sessions over time, and safety monitoring includes ensuring no allergic reactions to imaging materials. The study welcomes healthy volunteers and all ages, with informed consent or parental consent and patient assent as applicable.

Researchers are investigating oral disorders in extremely premature infants born before 29 weeks, focusing on the age at which these infants achieve full oral feeding without the need for tube feeding. The study aims to understand the development of oral skills in this population, as oral disorders can lead to delayed feeding autonomy and longer hospital stays, impacting psychomotor and cognitive development. It also seeks to identify risk factors for delayed oral feeding and calculate the incidence of oral feeding disorders up to 24 months of age. The study monitors infants admitted to a neonatal unit where a daily tactile stimulation protocol of orality is applied by nurses and physiotherapists to support the development of oral skills. This protocol involves stroking cheeks and peri-oral and intra-oral areas to encourage oral feeding autonomy. The study is observational and focuses on infants born between 2018 and 2021 who received this care approach during their hospital stay. Participants will be followed from birth until they reach full oral feeding autonomy, with the main measurement being the corrected gestational age at this time, observed up to two months. Researchers will also analyze risk factors for delayed oral feeding and track oral feeding disorders over a longer term. Data collection includes monitoring feeding progress and hospital discharge details, with participant involvement ending when oral feeding autonomy is achieved or after 24 months for disorder incidence assessment.

The trial investigates whether a single intravenous infusion of Amimestrocel injection, a cell therapy made from human umbilical cord mesenchymal stem cells, can help reduce severe mouth sores called oral mucositis in adults undergoing myeloablative allogeneic hematopoietic stem cell transplantation (HSCT). This painful side effect commonly occurs due to strong chemotherapy regimens containing total body irradiation (TBI) and/or melphalan. The study is a Phase 2, single-center, open-label exploratory trial involving about 22 adult patients aged 18 to 65 years. Participants will receive a single fixed dose of Amimestrocel injection (6.0 × 10^7 cells in 12 mL) intravenously within 24 to 48 hours after the last dose of cyclophosphamide, which is part of the standard conditioning regimen, and before the stem cell infusion (Day 0). All patients will also undergo standard myeloablative conditioning containing TBI and/or melphalan, followed by allogeneic stem cell transplantation and standard supportive care. During the study, patients will be closely monitored daily for the presence and severity of oral mucositis and pain for 28 days after transplant. Researchers will assess pain levels, opioid use, diarrhea, and time until blood counts recover. Safety will be followed for 100 days post-transplant, including adverse events and serious adverse events. The main outcome is the incidence of severe (Grade 3-4) oral mucositis within 28 days after transplant.

This research aims to understand how inflammation in the mouth affects the immune response during wound healing after tooth extraction. The study involves healthy adults aged 21 to 70 who need a posterior tooth extracted. Researchers will measure periodontal inflammation and take dental X-rays before the extraction to gather baseline information. Participants will undergo an atraumatic extraction of the affected tooth using local anesthesia. Small soft tissue biopsies from the extraction site will be collected immediately after extraction and again two weeks later when sutures are removed. A final visit at three months post-extraction will include clinical assessments and dental X-rays to evaluate healing. Throughout the study, researchers will collect data such as probing depths, gum recession, bleeding, and fluid samples from adjacent teeth. The soft tissue samples will be analyzed to count inflammatory cells and study immune activity during healing. Participants will be involved in three main visits over about three months, with careful monitoring of healing and inflammation.

This research aims to compare the effects of remimazolam and propofol on recovery time, complications, and safety in adult patients undergoing ambulatory upper airway surgery under general anesthesia. The trial focuses on surgeries involving the nasal cavity, oral cavity, pharynx, and larynx, evaluating which anesthesia method may influence postoperative recovery quality. Participants are randomly assigned to either the Remimazolam group or the Propofol group. In the Remimazolam group, anesthesia is started and maintained by continuous infusion of remimazolam and remifentanil, with recovery supported by flumazenil. In the Propofol group, anesthesia uses continuous infusion of propofol and remifentanil via target concentration controlled infusion. Both groups receive rocuronium for muscle relaxation and sugammadex to reverse this effect after surgery. During the study, recovery times and adverse events are recorded at three stages: in the operating room, in the post-anesthesia care unit (PACU), and in the day surgery center. Assessments include eye opening time, extubation time, PACU transfer time, stay durations, pain scores, alertness levels, and safety monitoring over several hours following surgery. The primary outcome is the time until patients are fit for discharge, measured 15 minutes after surgery.

Researchers are investigating the effects of St. John's wort extract on patients with Recurrent Aphthous Stomatitis (RAS), a condition that causes painful mouth ulcers and lacks a definitive treatment. The study aims to compare the healing and pain relief benefits of St. John's wort with two other commonly used treatments: triamcinolone acetonide, a corticosteroid, and hyaluronic acid gel. RAS causes discomfort in oral functions, and this research seeks to find better ways to reduce pain and promote ulcer healing.

Researchers are evaluating the effectiveness of an antioxidant mouthwash containing resveratrol in reducing oral malodor (bad breath) and the bacteria Porphyromonas gingivalis among undergraduate dental students with plaque-induced gingivitis. The study also aims to explore the relationship between this bacteria and clinical gum health measures such as plaque index, gingival index, and bleeding on probing. This is a randomized, triple-blind clinical trial involving students aged 20 to 23 without systemic diseases or recent periodontal treatment. Participants will be divided into three groups of 18 each. One group will use the resveratrol mouthwash, the second group will use chlorhexidine mouthwash as an active comparator, and the third will use distilled water as a placebo. All will rinse twice daily with 10 ml of the assigned mouthwash for 30 seconds, after brushing their teeth, over a 7-day period. They will be reminded twice daily by text message to maintain compliance and instructed to avoid eating or drinking for 30 minutes after rinsing. During the study, participants will complete questionnaires covering personal information, oral hygiene habits, and perceptions of oral malodor. Clinical assessments will include plaque index, gingival index, bleeding on probing, and organoleptic odor tests of the tongue and interdental areas. A portable sulfide monitor will confirm halitosis levels. These measures will be recorded at baseline and after 7 days of mouthwash use. Participants will also provide feedback on mouthwash taste and sensations using a visual scale. Safety monitoring includes advice to stop use if allergic reactions occur.

Researchers are evaluating the STRATICYTE12 predictive model to see how well it can predict the transformation of oral potentially malignant disorders (OPMDs) into oral squamous cell carcinoma (OSCC). This study focuses on a retrospective group of patients who had biopsies taken for oral lesions. The main goals include assessing the model's sensitivity and specificity, understanding which patient and clinical factors affect its accuracy, and estimating how STRATICYTE12 results relate to the time until a positive oral cancer diagnosis. The study involves analyzing biopsy tissue samples from patients with various grades of oral epithelial dysplasia, including no dysplasia, mild, moderate, severe dysplasia, and carcinoma in situ (CIS). Participants are grouped based on whether their OPMDs progressed to OSCC or not. STRATICYTE12 testing is used to assess the risk of progression to oral cancer by reviewing archived biopsy tissue blocks from clinical centers. Participants' archived biopsy data and clinical follow-up records over at least five years are reviewed. Researchers measure the STRATICYTE12 test's sensitivity, specificity, area under the curve (AUC), and Harrell's C-index, along with survival analysis over five years. The study tracks the correlation of STRATICYTE12 outcomes with oral cancer development timing. No new treatments or procedures are performed during this observational study, and the overall participation involves data analysis from past biopsies and clinical records.

Researchers are evaluating the safety of using the galea and pericranium (fascio-periosteal) temporal flap for reconstructing mandibular gingival defects. This approach aims to improve function and appearance after surgical removal of oral cavity tumors. The study builds on previous experiences where similar flaps have been used successfully for head and neck reconstruction, including bone regeneration and treatment of pharyngeal fistulas. The study involves patients who need reconstruction following partial removal of the mandibular gingival region. Surgeons will use periosteum, galea, or pericranium flaps harvested from the cranial temporal region, which has good blood supply, to repair soft and hard tissue defects. This method is being assessed as a reliable option for oral cavity reconstruction after tumor excision. Participants will be followed for at least 18 months to monitor outcomes. Researchers will evaluate the function and safety of the flap reconstruction, including bone and tissue healing. Patients will have regular follow-up visits for assessments, and their progress will be closely monitored to measure the success of the surgical procedure and any related complications.