Periodontitis

Researchers are evaluating the effect of Ibuprofen on reducing the acute inflammatory response after one-stage non-surgical periodontal therapy in adults with periodontitis. The study aims to answer whether Ibuprofen effectively lowers markers of inflammation such as hs-CRP, Procalcitonin, and IL-6 following this dental treatment. This is a randomized clinical trial focused on patients with generalized unstable periodontitis and a pocket depth of 4 mm or more. Participants will first attend a baseline visit where demographic information, clinical examination, and baseline blood samples will be collected. All will receive scaling and oral hygiene instructions, and one week later, clinical parameters will be recorded again. The test group will receive Ibuprofen doses starting one hour before root surface debridement and continuing three times daily for three days, while the control group will undergo the same dental procedure without Ibuprofen. Root surface debridement will be performed by a single periodontist, and treatment duration will be recorded. Participants will attend a follow-up visit one week after root surface debridement to collect blood samples, complete a pain questionnaire, and record plaque index to assess oral hygiene compliance. The main outcomes measured are changes in systemic inflammatory markers after seven days and postoperative pain using a visual analog scale. The study involves active monitoring of clinical parameters and patient-reported pain over the course of one week following treatment.

Researchers are evaluating the effect of a processed blood product called liquid platelet-rich fibrin (S-PRF) in helping healing after treatment for severe gum disease (periodontitis) stages II to IV. This study compares the use of the blood-derived material with standard treatment using saline irrigation, aiming to see if the blood product improves gum healing after deep cleaning procedures. Participants have severe gum disease with symptoms like bleeding, receding gums, loose teeth, and swelling. Participants will receive standard treatment involving full mouth scaling, root debridement, and cleaning with local anesthesia. After treatment, about 20 mL of blood will be taken to produce liquid S-PRF, which will be used to flush gum pockets on one side of the mouth. The other side will receive saline irrigation as a comparison. Follow-up visits are scheduled monthly for 3 months to monitor healing and outcomes. During the study, participants will undergo dental exams, X-rays, and jaw mold making. They will also receive oral care instructions and kits. Researchers will measure gum probing depth, clinical attachment level, bleeding sites, plaque scores, and gum margin changes before treatment and after 3 months. Safety and healing progress will be closely monitored throughout the study duration, which lasts about 3 months.

Researchers are studying the usefulness of 3D-printed tooth replicas combined with autotransplantation of teeth in children and young adults who need tooth transplantation. This study is designed to compare the 3D generated tooth replicas with the conventional methods to see if the new technology improves the surgical process and success of tooth transplantation. The study is led by Turku University Hospital and includes participants aged 9 to 23 years. Participants will undergo tooth autotransplantation surgery using either a 3D-printed tooth replica or a conventional procedure. Researchers will evaluate factors such as the duration of surgery and the degree of manipulation needed during the transplant procedure. They will also assess how well the transplanted tooth erupts and develops its roots over time. Participants will be followed for one year after surgery. During this time, clinical and radiological examinations will be performed to determine the health of the transplanted teeth. The main outcomes measured include the number of patients with healthy transplanted teeth at one year. This monitoring will help researchers understand the effectiveness of using 3D replicas in tooth autotransplantation.

Researchers are evaluating the effects of two types of free gingival graft surgeries—conventional free gingival graft (FGG) and modified free gingival graft (ModFGG)—on soft tissue thickness, volume, and creeping attachment in the lower front teeth. This trial involves 34 healthy, non-smoking adults with localized Cairo Class II gingival recession. The goal is to understand how the modified technique may improve soft tissue stability and volume compared to the conventional method, using advanced three-dimensional digital analysis. Participants will be randomly assigned to receive either the conventional FGG procedure or the modified ModFGG procedure. The ModFGG involves creating a connective tissue flap from the recession area to cover the exposed root before placing a graft from the palate, aiming to enhance blood supply and healing. The conventional FGG involves placing a graft from the palate directly onto the prepared site without this flap. Both procedures will be followed by digital and clinical assessments at baseline, and at 1, 3, and 6 months after surgery. During the study, participants will undergo clinical measurements including gingival recession depth, keratinized tissue width, and probing depth, alongside three-dimensional digital scans with an intraoral scanner to evaluate soft tissue thickness and volume changes. These evaluations at multiple time points will help assess tissue stability and healing progress. The study will last at least six months post-surgery, providing detailed information on soft tissue outcomes and healing after these grafting procedures.

Researchers are comparing the survival rates of different ceramic dental implants in adults with missing or hopeless teeth. This observational study focuses on two types of CeraRoot ceramic implants: one-piece and two-piece (TL) models. The study aims to determine if there are significant differences in implant survival and to identify any complications associated with the procedures in these groups. The study involves patients from two dental centers in Barcelona, Spain, and Boulder, Colorado, USA. Participants will receive either one-piece or two-piece CeraRoot ceramic dental implants. These implants are specially designed for patients with metal allergies or chronic illnesses related to metal allergies. The study will follow patients for at least 12 months after enrollment to monitor implant survival and complications. During the study, researchers will collect information on implant survival rates and any complications occurring within one year after treatment. Participants will undergo dental assessments to evaluate implant status and oral health. The study's main outcome is the survival rate of the implants over 12 months or longer. This long-term follow-up helps understand the performance and safety of these ceramic dental implants in real-world clinical settings.

This clinical trial evaluates the effectiveness of an antimicrobial mouthrinse in reducing established dental plaque and improving gum health in adults with gingivitis and dental plaque accumulation. The study focuses on measuring improvements in gum health using the Gingival Index and plaque reduction using the Plaque Index over a six-month period. Participants include adults aged 18 to 70 years who have at least 20 natural teeth and meet specific oral health criteria. Participants are randomly assigned to one of two groups: the test group using a mouthrinse containing 0.0553% sodium fluoride, amine, and 0.2% zinc lactate dihydrate, or the control group using a mouthrinse with 0.0553% sodium fluoride only. Both groups will brush their teeth twice daily with provided toothpaste and toothbrush, then rinse with 15 ml of the assigned mouthrinse for 30 seconds. This routine continues for six months. Throughout the study, participants visit the clinic every three months after the baseline visit for reassessment. Researchers monitor gum health improvements and plaque levels using standardized indices. The study also includes safety monitoring and requires participants to maintain good general health and adhere to the treatment regimen. The total duration of participation is six months, with regular assessments to evaluate treatment effects.

Researchers are evaluating the clinical performance of a new generation of customized CAD/CAM pre-fabricated root-analog dental implants in patients who have experienced tooth loss. This observational prospective cohort study aims to determine if these drilling-free implants are safe, effective, and clinically viable over a 36-month period and whether they provide better post-operative outcomes compared to traditional implant methods. The study is conducted by the University of Sao Paulo. Participants in this study have received personalized dental implants using the iDENTICAL Dental Implant System immediately after tooth extraction during a previous interventional phase. This study follows a single group of twelve patients over 36 months, monitoring the implants at 12, 24, and 36 months after prosthesis installation. The focus is on assessing implant survival, peri-implant tissue health, post-operative comfort, bone preservation, and tissue integration. During the study, participants will undergo clinical and radiographic examinations at the specified time points to measure radiographic success, changes in peri-implant soft tissues, prosthetic outcomes, and other peri-implant clinical parameters. The study requires availability for follow-up visits throughout the 36-month observation period. Safety and efficacy data will be collected to understand the long-term outcomes of these customized dental implants.

Researchers are evaluating non-surgical treatment options for patients with stage III or IV periodontitis who have specific Class II buccal and/or lingual furcation defects in their mandibular and maxillary molars. This prospective, randomized, single-blinded clinical trial uses a split-mouth design to compare treatments and is conducted at Riga Stradins University Institute of Stomatology in Latvia. Patients receive detailed oral hygiene instructions before treatment begins to ensure proper care. The study compares two treatments: the test side receives an oscillating chitosan brush combined with enamel matrix derivatives, while the control side receives the oscillating chitosan brush alone. Treatment is applied to furcation defects at baseline. The trial includes a 12-week re-evaluation period after baseline treatment. Biofilm and gingival crevicular fluid samples are collected at baseline and again at 4 weeks to monitor biological changes. Participants undergo clinical assessments including bleeding on probing, probing pocket depth, clinical attachment level, and furcation involvement measurements at baseline and 12 weeks. Proteomic and microbiological analyses of gingival fluid and plaque samples are performed at baseline and 4 weeks. Patient comfort is measured using a visual analog scale at baseline. The trial involves follow-up visits to monitor periodontal status and treatment effects over 12 weeks.

Researchers are conducting a prospective, observational, multicenter study to evaluate the TSX dental implant system in patients needing implants in the upper jaw (maxilla) or lower jaw (mandible). The study aims to assess the safety, effectiveness, and clinical performance of these implants, with a focus on implant integration success and bone level changes over two years. Patients with prior failed implants, major bone grafting needs, or implant revisions are not eligible for this study. Participants will receive TSX dental implants and will have either a temporary prosthesis placed immediately or within 48 hours, or a temporary or final prosthesis placed between 3 to 16 weeks after implant surgery. The final restoration will occur no later than four months after implant placement, using the full range of ZimVie prosthetic systems. The study plans to enroll approximately 60 patients, with a total of 62 implants placed across all sites. During the study, patients will return for yearly follow-up visits over two years to evaluate implant integration success and implant survival. Researchers will measure primary stability during placement and monitor changes in bone levels around the implants at various visits. Participants must agree to be evaluated at each study visit and provide informed consent. The total duration of follow-up is two years after implant placement surgery.

Researchers are evaluating an experimental toothpaste containing 0.454% stannous fluoride (SnF2) to see if it can improve gum health and reduce plaque better than a regular fluoride toothpaste in adults with mild to moderate gingivitis. This 24-week, randomized, controlled, examiner-blind study includes about 300 participants divided into three groups to compare the experimental toothpaste with a marketed SnF2 toothpaste and a regular fluoride toothpaste. Participants will brush their teeth twice daily for at least one minute using either the experimental dentifrice, a marketed dentifrice with SnF2, or a regular fluoride dentifrice. Each treatment lasts for 24 weeks, with the goal of assessing differences in gingival health and plaque accumulation across the three groups. During the study, participants will be regularly evaluated for gingival bleeding and plaque levels at weeks 1, 4, 12, and 24 using standardized indices. Researchers will monitor gum health and plaque reduction to measure the toothpaste effectiveness. The primary outcome is the number of bleeding sites at week 24, and safety and adherence will be observed throughout the trial.