Periodontitis

Researchers are evaluating the effect of Ibuprofen on reducing the acute inflammatory response after one-stage non-surgical periodontal therapy in adults with periodontitis. The study aims to answer whether Ibuprofen effectively lowers markers of inflammation such as hs-CRP, Procalcitonin, and IL-6 following this dental treatment. This is a randomized clinical trial focused on patients with generalized unstable periodontitis and a pocket depth of 4 mm or more. Participants will first attend a baseline visit where demographic information, clinical examination, and baseline blood samples will be collected. All will receive scaling and oral hygiene instructions, and one week later, clinical parameters will be recorded again. The test group will receive Ibuprofen doses starting one hour before root surface debridement and continuing three times daily for three days, while the control group will undergo the same dental procedure without Ibuprofen. Root surface debridement will be performed by a single periodontist, and treatment duration will be recorded. Participants will attend a follow-up visit one week after root surface debridement to collect blood samples, complete a pain questionnaire, and record plaque index to assess oral hygiene compliance. The main outcomes measured are changes in systemic inflammatory markers after seven days and postoperative pain using a visual analog scale. The study involves active monitoring of clinical parameters and patient-reported pain over the course of one week following treatment.

Researchers are evaluating the effect of a processed blood product called liquid platelet-rich fibrin S-PRF in helping healing after treatment for severe gum disease periodontitis stages II to IV. This study compares the use of the blood-derived material with standard treatment using saline irrigation, aiming to see if the blood product improves gum healing after deep cleaning procedures. Participants have severe gum disease with symptoms like bleeding, receding gums, loose teeth, and swelling. Participants will receive standard treatment involving full mouth scaling, root debridement, and cleaning with local anesthesia. After treatment, about 20 mL of blood will be taken to produce liquid S-PRF, which will be used to flush gum pockets on one side of the mouth. The other side will receive saline irrigation as a comparison. Follow-up visits are scheduled monthly for 3 months to monitor healing and outcomes. During the study, participants will undergo dental exams, X-rays, and jaw mold making. They will also receive oral care instructions and kits. Researchers will measure gum probing depth, clinical attachment level, bleeding sites, plaque scores, and gum margin changes before treatment and after 3 months. Safety and healing progress will be closely monitored throughout the study duration, which lasts about 3 months.

Researchers are studying the usefulness of 3D-printed tooth replicas combined with autotransplantation of teeth in children and young adults who need tooth transplantation. This study is designed to compare the 3D generated tooth replicas with the conventional methods to see if the new technology improves the surgical process and success of tooth transplantation. The study is led by Turku University Hospital and includes participants aged 9 to 23 years. Participants will undergo tooth autotransplantation surgery using either a 3D-printed tooth replica or a conventional procedure. Researchers will evaluate factors such as the duration of surgery and the degree of manipulation needed during the transplant procedure. They will also assess how well the transplanted tooth erupts and develops its roots over time. Participants will be followed for one year after surgery. During this time, clinical and radiological examinations will be performed to determine the health of the transplanted teeth. The main outcomes measured include the number of patients with healthy transplanted teeth at one year. This monitoring will help researchers understand the effectiveness of using 3D replicas in tooth autotransplantation.

Researchers are evaluating the effects of two types of free gingival graft surgeriesconventional free gingival graft FGG and modified free gingival graft ModFGGon soft tissue thickness, volume, and creeping attachment in the lower front teeth. This trial involves 34 healthy, non-smoking adults with localized Cairo Class II gingival recession. The goal is to understand how the modified technique may improve soft tissue stability and volume compared to the conventional method, using advanced three-dimensional digital analysis. Participants will be randomly assigned to receive either the conventional FGG procedure or the modified ModFGG procedure. The ModFGG involves creating a connective tissue flap from the recession area to cover the exposed root before placing a graft from the palate, aiming to enhance blood supply and healing. The conventional FGG involves placing a graft from the palate directly onto the prepared site without this flap. Both procedures will be followed by digital and clinical assessments at baseline, and at 1, 3, and 6 months after surgery. During the study, participants will undergo clinical measurements including gingival recession depth, keratinized tissue width, and probing depth, alongside three-dimensional digital scans with an intraoral scanner to evaluate soft tissue thickness and volume changes. These evaluations at multiple time points will help assess tissue stability and healing progress. The study will last at least six months post-surgery, providing detailed information on soft tissue outcomes and healing after these grafting procedures.

Researchers are comparing the survival rates of different ceramic dental implants in adults with missing or hopeless teeth. This observational study focuses on two types of CeraRoot ceramic implants one-piece and two-piece TL models. The study aims to determine if there are significant differences in implant survival and to identify any complications associated with the procedures in these groups. The study involves patients from two dental centers in Barcelona, Spain, and Boulder, Colorado, USA. Participants will receive either one-piece or two-piece CeraRoot ceramic dental implants. These implants are specially designed for patients with metal allergies or chronic illnesses related to metal allergies. The study will follow patients for at least 12 months after enrollment to monitor implant survival and complications. During the study, researchers will collect information on implant survival rates and any complications occurring within one year after treatment. Participants will undergo dental assessments to evaluate implant status and oral health. The studys main outcome is the survival rate of the implants over 12 months or longer. This long-term follow-up helps understand the performance and safety of these ceramic dental implants in real-world clinical settings.

This clinical trial evaluates the effectiveness of an antimicrobial mouthrinse in reducing established dental plaque and improving gum health in adults with gingivitis and dental plaque accumulation. The study focuses on measuring improvements in gum health using the Gingival Index and plaque reduction using the Plaque Index over a six-month period. Participants include adults aged 18 to 70 years who have at least 20 natural teeth and meet specific oral health criteria. Participants are randomly assigned to one of two groups the test group using a mouthrinse containing 0.0553% sodium fluoride, amine, and 0.2% zinc lactate dihydrate, or the control group using a mouthrinse with 0.0553% sodium fluoride only. Both groups will brush their teeth twice daily with provided toothpaste and toothbrush, then rinse with 15 ml of the assigned mouthrinse for 30 seconds. This routine continues for six months. Throughout the study, participants visit the clinic every three months after the baseline visit for reassessment. Researchers monitor gum health improvements and plaque levels using standardized indices. The study also includes safety monitoring and requires participants to maintain good general health and adhere to the treatment regimen. The total duration of participation is six months, with regular assessments to evaluate treatment effects.

Researchers are evaluating the clinical performance of a new generation of customized CADCAM pre-fabricated root-analog dental implants in patients who have experienced tooth loss. This observational prospective cohort study aims to determine if these drilling-free implants are safe, effective, and clinically viable over a 36-month period and whether they provide better post-operative outcomes compared to traditional implant methods. The study is conducted by the University of Sao Paulo. Participants in this study have received personalized dental implants using the iDENTICAL Dental Implant System immediately after tooth extraction during a previous interventional phase. This study follows a single group of twelve patients over 36 months, monitoring the implants at 12, 24, and 36 months after prosthesis installation. The focus is on assessing implant survival, peri-implant tissue health, post-operative comfort, bone preservation, and tissue integration. During the study, participants will undergo clinical and radiographic examinations at the specified time points to measure radiographic success, changes in peri-implant soft tissues, prosthetic outcomes, and other peri-implant clinical parameters. The study requires availability for follow-up visits throughout the 36-month observation period. Safety and efficacy data will be collected to understand the long-term outcomes of these customized dental implants.

Researchers are evaluating non-surgical treatment options for patients with stage III or IV periodontitis who have specific Class II buccal andor lingual furcation defects in their mandibular and maxillary molars. This prospective, randomized, single-blinded clinical trial uses a split-mouth design to compare treatments and is conducted at Riga Stradins University Institute of Stomatology in Latvia. Patients receive detailed oral hygiene instructions before treatment begins to ensure proper care. The study compares two treatments the test side receives an oscillating chitosan brush combined with enamel matrix derivatives, while the control side receives the oscillating chitosan brush alone. Treatment is applied to furcation defects at baseline. The trial includes a 12-week re-evaluation period after baseline treatment. Biofilm and gingival crevicular fluid samples are collected at baseline and again at 4 weeks to monitor biological changes. Participants undergo clinical assessments including bleeding on probing, probing pocket depth, clinical attachment level, and furcation involvement measurements at baseline and 12 weeks. Proteomic and microbiological analyses of gingival fluid and plaque samples are performed at baseline and 4 weeks. Patient comfort is measured using a visual analog scale at baseline. The trial involves follow-up visits to monitor periodontal status and treatment effects over 12 weeks.

Researchers are conducting a prospective, observational, multicenter study to evaluate the safety, effectiveness, and clinical performance of the TSX dental implant system in patients needing implants in the upper or lower jaw maxilla or mandible. This study involves 62 implants placed in approximately 60 patients who require dental implants to treat tooth loss, excluding those with prior implant failures or major bone grafting needs. The study aims to observe implant integration success and survival over a 2-year period. Participants will receive dental implants using the TSX dental implant system, with temporary prostheses placed either immediately during the implant surgery or within 48 hours, or between 3 to 16 weeks after implant placement. Final restorative treatments using the full range of ZimVie prosthetic systems will be completed no later than 4 months following implant surgery. All implants and restorations will be monitored yearly for 2 years. During the study, participants will attend follow-up visits yearly for 2 years to assess implant integration, survival, and changes in bone levels around the implant sites. Evaluations will include clinical examinations and imaging to measure bone regression and implant stability. Participants must agree to be evaluated at each study visit and provide informed consent. Total participation spans from implant placement surgery through the 2-year follow-up.

Gingival recessions are a common issue affecting many adults worldwide and can lead to problems such as tooth sensitivity, root caries, and aesthetic concerns. This trial aims to compare a new volume stable collagen matrix to the standard connective tissue graft from the palate in treating gingival recessions, particularly in orthodontically treated patients. The study seeks to improve understanding of the best treatment methods for both upper and lower jaw recessions to enhance periodontal health and patient outcomes. Participants will be randomly assigned to one of two treatment groups. The test group will receive tissue thickening using the collagen matrix combined with a modified coronally advanced tunnel technique. The control group will undergo the standard treatment involving a connective tissue graft harvested from the palate with the same surgical technique. Both procedures aim to cover the gingival recession defect effectively. During the study, researchers will assess root coverage, early wound healing, tissue thickness increase, clinical attachment level, aesthetic scores, and patient satisfaction over a one-year period. Follow-up evaluations will include wound healing checks within the first week after surgery and assessments of periodontal tissue changes and patient-reported outcomes at one year. Participation includes regular visits and clinical measurements to monitor treatment effects and safety.