Actively Recruiting
CORALINE - Correlation Between Physiological and Clinical Variables and Failure of Non-Invasive Respiratory Support in Patients With Acute Respiratory Failure
Led by University of Modena and Reggio Emilia · Updated on 2026-01-22
325
Participants Needed
1
Research Sites
269 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This observational study aims to evaluate the relationship between clinical and physiological variables and the failure of non-invasive respiratory support (NIRS), including high-flow nasal oxygen (HFNO) and non-invasive ventilation (NIV), in patients with acute respiratory failure (ARF), both hypoxemic and/or hypercapnic. The study includes both retrospective and prospective components. Retrospective data will be collected from patient charts, while prospective data will be collected at defined time points during clinical care. The primary outcome is NIRS failure, defined as the need for orotracheal intubation. Secondary outcomes include in-hospital and 90-day mortality, ICU and hospital length of stay, and duration of non-invasive and invasive support.
CONDITIONS
Official Title
CORALINE - Correlation Between Physiological and Clinical Variables and Failure of Non-Invasive Respiratory Support in Patients With Acute Respiratory Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age �3E= 18 years
- Hospitalized in the Respiratory Medicine Unit at AOU Policlinico di Modena
- Acute respiratory failure (hypoxemic and/or hypercapnic) with PaO8/FiO8 < 300 mmHg
- Receiving treatment with high-flow nasal oxygen or non-invasive ventilation
You will not qualify if you...
- Immediate need for invasive ventilation upon admission
- Known neuromuscular disease
- Pregnancy
- Lack of informed consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
AOU Policlinico di Modena
Modena, Italy, 41125
Actively Recruiting
Research Team
R
Roberto Tonelli, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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