Study of Transesophageal Pressure and Its Link to Non-invasive Respiratory Support Failure in Adults with Acute Low Oxygen Respiratory Failure

What this Trial Is About

Researchers are evaluating the relationship between transesophageal pressure and respiratory mechanics, including nasal pressure Pnose, and their connection to failure of non-invasive respiratory support in patients with acute hypoxic respiratory failure from various causes, including COVID-19. This observational study aims to better understand these pressures and mechanics to help inform treatment approaches for this condition. The study involves observing patients who have acute hypoxic respiratory failure and measuring esophageal pressure, nasal pressure, transpulmonary pressure, dynamic compliance, and mechanical power. These measurements will be analyzed to see how they relate to the success or failure of non-invasive respiratory support within the first 24 hours of treatment. Participants will be monitored closely with respiratory and pressure measurements taken during their care. The main outcome is the impact of esophageal pressure on non-invasive respiratory support failure within 24 hours. Additional outcomes include effects of other respiratory pressures and mechanics on support failure. The study will continue until December 2027, and participants health data will be collected during their hospital care period.

Correlation Between Trans Esophageal Pressure and Non-invasive Respiratory Support Failure in Patients With Acute Hypoxic Respiratory Failure