Study of Vaspin Gene Variations and Serum Levels in Adults Aged 18 to 50 with Psoriasis Vulgaris and Their Role in Disease Risk and Development

What this Trial Is About

Psoriasis vulgaris is a common immune-related inflammatory skin condition that affects many people worldwide, including those in Egypt. It causes red, scaly plaques on the skin and can significantly reduce quality of life. This study explores the role of vaspin, an adipokine produced by fat tissue, and its gene variations in the development and severity of psoriasis. Researchers aim to understand how vaspin gene polymorphism relates to psoriasis risk and disease progression. The study will involve about 30 patients with psoriasis vulgaris and 30 healthy participants as a control group. Researchers will measure vaspin gene polymorphism and assess disease severity using the Psoriasis Area and Severity Index PASI score. This observational study does not involve medical treatments but focuses on genetic and serum analysis to find links between vaspin and psoriasis. Participants will undergo genetic testing and severity assessments over a 12-month period. The main outcome is detecting vaspin gene polymorphism and its relationship to psoriasis. The study also monitors serum vaspin levels and disease severity. Participation involves regular evaluations but no experimental therapies. The study aims to improve understanding of psoriasis pathogenesis and potential markers for the disease.

Correlation Between Vaspin Gene Polymorphism and Serum Vaspin Levels in Psoriasis Vulgaris