Actively Recruiting
Definition of Mutational Profile of Papillary Thyroid Tumors by Mass-ARRAY
Led by Istituto Auxologico Italiano · Updated on 2024-10-08
600
Participants Needed
1
Research Sites
468 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Somatic mutations in the MAP (mitogen-activated protein) kinase pathway have been found in about 80% of papillary thyroid tumors (PTCs). The evaluation of the PTC mutational profile is crucial for the definition of the prognosis and for predicting the effects of targeted and personalized therapies. Molecular characterization by mass spectrometry (Mass ARRAY) allows the search for multiple mutations in a single experiment, in a sensitive, fast and economic way. A Mass ARRAY platform (PTC-MA) was developed, capable of identifying the presence of the most common somatic point mutations and rearrangements in PTC (Pesenti et al., Endocrine 2017). The aim of the study is to characterize the mutational profile of a large series of papillary thyroid carcinomas (PTC). Tumor samples will be analyzed using our PTC-MA platform. The molecular profile of PTCs will be correlated with the clinical and prognostic characteristics of the patients.
CONDITIONS
Official Title
Definition of Mutational Profile of Papillary Thyroid Tumors by Mass-ARRAY
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with papillary thyroid cancer
- Patients whose tumor tissue can be recovered for genetic analysis
You will not qualify if you...
- Patients who did not give consent
- Patients lost to follow-up
- Tumor samples not suitable for genetic analysis
AI-Screening
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Trial Site Locations
Total: 1 location
1
Istituto Auxologico Italiano
Milan, MI, Italy, 20145
Actively Recruiting
Research Team
M
Marina Muzza, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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