Monitoring Depth of Sedation Using Masimo EEG and NIRS in Adults with Acute Respiratory Distress Syndrome in the ICU

What this Trial Is About

Researchers are evaluating how feasible it is to monitor brain activity and tissue oxygen levels in patients with acute respiratory distress syndrome ARDS in the intensive care unit ICU. This study focuses on using processed transcutaneous electroencephalography EEG and near-infrared spectroscopy NIRS to better understand sedation depth and cerebrovascular reactivity in these patients. The goal is to improve monitoring techniques by assessing the relationship between brain oxygenation and sedation or blood pressure levels. Participants will have non-invasive devices called Masimo SedLine processed EEG and Masimo O3 NIRS applied to measure brain activity and tissue oxygenation StO2. The study will determine the optimal depth of sedation SEDopt and optimal blood pressure MAPopt that minimize the correlation between these measurements. Along with monitoring, demographic details, medical history, disease severity, routine blood tests, and sedation doses will also be recorded. During the study, participants will be closely monitored in the ICU for up to 7 days to collect data on sedation depth and blood pressure effects on brain oxygenation. Researchers will review recruitment progress over 20 months and assess data quality within the first week. This observational study involves continuous monitoring and documentation to understand sedation impacts on cerebrovascular function in ARDS patients, with no investigational treatments administered.

Depth of Sedation and Its Impact on Cerebrovascular Reactivity in Acute Respiratory Distress Syndrome: a Pilot Analysis