Regional Assessment of the Risk of Lung Injury in Ventilated Patients With Similar Lung Load

What this Trial Is About

Researchers are studying the risk of lung injury caused by mechanical ventilation in patients with acute respiratory distress syndrome (ARDS). The study focuses on how different lung characteristics like functional capacity, uneven lung aeration, and alveolar stability affect the chance of ventilator-induced lung injury, even when using similar safe ventilation settings. This observational study aims to better understand injury mechanisms occurring in different lung regions during ventilation in the supine position. The study observes patients receiving controlled mechanical ventilation where tidal volume, respiratory rate, and plateau pressure are kept similar. Positive end-expiratory pressure (PEEP) is adjusted to maintain a similar plateau pressure. Researchers compare lung injury mechanisms between the ventral (front) and dorsal (back) halves of the lung, evaluating regional lung volume, lung deformation, hyperinflated areas, and unstable lung tissue. Participants will be monitored during one-hour assessment periods where lung volumes and deformations are measured regionally. Various clinical parameters and imaging may be used to assess lung mechanics and injury risk. The research team will analyze these measurements to understand differences in lung response to ventilation. The study excludes patients with certain lung diseases or conditions that could interfere with monitoring or pose safety risks. The overall participation duration and follow-up depend on patient condition and study protocols.

Regional Assessment of the Risk of Lung Injury in Ventilated Patients