Study of Clinical and Molecular Factors in Chronic Inflammatory Skin Diseases Including Atopic Dermatitis and Psoriasis

What this Trial Is About

Researchers are studying chronic inflammatory skin diseases such as atopic dermatitis, psoriasis, and hidradenitis suppurativa, which show great variation in symptoms, severity, and treatment responses. The goal is to identify clinical and molecular factors that relate to disease subtypes and progression by closely following patients over a long period. This observational study aims to improve understanding of the natural course and variability of these conditions to help personalize patient care. Participants will be monitored through regular visits where clinical assessments and biological samples are collected. The study does not assign specific treatments but follows patients regardless of whether they use topical or systemic drugs. Evaluations occur at baseline, week 2, week 4, and then every three months for up to two years to capture changes in disease activity and molecular profiles over time. During the study, patients will undergo physician and patient assessments of disease activity, along with molecular testing from collected specimens. These measures are repeated regularly to track disease dynamics and flare-ups. The study includes safety considerations such as excluding recent use of certain immunosuppressive therapies. Participation can last up to two years, aiming to gather comprehensive data on disease progression and contributing factors.

Determinants of Chronic Inflammatory Skin Disease Trajectories