Actively Recruiting
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
Led by Massachusetts General Hospital · Updated on 2025-11-03
8000
Participants Needed
31
Research Sites
286 weeks
Total Duration
On this page
Sponsors
M
Massachusetts General Hospital
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients at risk for dementia (decline in memory, thinking and other mental abilities that significantly affects daily functioning) after their stroke so that future treatments may be developed to improve outcomes in stroke patients. For this study, a "stroke" is defined as either (1) an acute ischemic stroke (AIS, or blood clot in the brain), (2) an intracerebral hemorrhage (ICH, or bleeding in the brain), (3) or an aneurysmal subarachnoid hemorrhage (aSAH, or bleeding around the brain caused by an abnormal bulge in a blood vessel that bursts). The investigators hypothesize that: 1. The size, type and location of the stroke play an important role in recovery of thinking and memory abilities after stroke, and pre-existing indicators of brain health further determine the extent of this recovery. 2. Specific stroke events occurring in individuals with underlying genetic or biological risk factors can cause further declines in brain heath, leading to changes in thinking and memory abilities after stroke. 3. Studying thinking and memory alongside brain imaging and blood samples in patients who have had a stroke allows for earlier identification of declining brain health and development of individualized treatment plans to improve patient outcomes in the future.
CONDITIONS
Official Title
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Admitted to the enrolling hospital with a diagnosis of acute ischemic stroke, intracerebral hemorrhage, or aneurysmal subarachnoid hemorrhage
- Radiographic confirmation of stroke type based on MRI or CT scans
- Able to complete baseline visit in person or by phone within 6 weeks of stroke onset
- Able to provide informed consent by self or proxy
- Fluent in English or Spanish prior to stroke onset
You will not qualify if you...
- History of pre-stroke dementia or fails dementia pre-screen
- Currently enrolled in a study not approved under the DISCOVERY Co-Enrollment Policy
- Unable to complete study protocol due to severe medical or behavioral conditions, or comfort measures only
- For Tier 2: Contraindications to MRI such as having certain implants or metallic brain clips
- For Tier 3: Under 50 years of age
- For Tier 3: Biological females who are pregnant or planning pregnancy
- For Tier 3: Known genetic conditions increasing cancer risk, including Cowden disease, Lynch syndrome, hypogammaglobulinemia, Wiskott-Aldrich syndrome, Down's syndrome
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 31 locations
1
Barrow Neurological Institute
Phoenix, Arizona, United States, 85013
Actively Recruiting
2
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, United States, 90027
Actively Recruiting
3
Cedars Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
4
University of California Los Angeles
Los Angeles, California, United States, 90095
Actively Recruiting
5
University of California San Diego
San Diego, California, United States, 92037
Actively Recruiting
6
University of Colorado
Denver, Colorado, United States, 80045
Actively Recruiting
7
Mayo Clinic
Jacksonville, Florida, United States, 32224
Actively Recruiting
8
University of Miami Health System
Miami, Florida, United States, 33125
Actively Recruiting
9
The University of Chicago Medical Center
Chicago, Illinois, United States, 60637
Actively Recruiting
10
Indiana University
Indianapolis, Indiana, United States, 46202
Actively Recruiting
11
University of Iowa
Iowa City, Iowa, United States, 52242
Active, Not Recruiting
12
University of Maryland Medical Center
Baltimore, Maryland, United States, 21201
Actively Recruiting
13
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
14
Boston Medical Center
Boston, Massachusetts, United States, 02118
Actively Recruiting
15
University of Michigan
Ann Arbor, Michigan, United States, 48109
Active, Not Recruiting
16
University of Minnesota Health
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
17
Mayo Clinic
Rochester, Minnesota, United States, 55902
Actively Recruiting
18
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216
Actively Recruiting
19
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029
Actively Recruiting
20
Montefiore Medical Center
The Bronx, New York, United States, 10467
Actively Recruiting
21
Duke University Medical Center
Durham, North Carolina, United States, 27708
Actively Recruiting
22
Wake Forest Baptist Health
Winston-Salem, North Carolina, United States, 27157
Active, Not Recruiting
23
University of Cincinnati
Cincinnati, Ohio, United States, 45219
Actively Recruiting
24
The Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
25
Methodist University Hospital
Memphis, Tennessee, United States, 38104
Actively Recruiting
26
Houston Methodist Research Institute
Houston, Texas, United States, 77030
Actively Recruiting
27
UTHealth
Houston, Texas, United States, 77030
Actively Recruiting
28
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229
Actively Recruiting
29
University of Utah
Salt Lake City, Utah, United States, 84132
Actively Recruiting
30
University of Virginia
Charlottesville, Virginia, United States, 22903
Actively Recruiting
31
University of Washington, Harborview Medical Center
Seattle, Washington, United States, 98104
Actively Recruiting
Research Team
J
James Meschia, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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