Actively Recruiting
Incidence of Neurocognitive Deficits After Treatment for Pediatric Retinoblastoma With Multiple Anesthesia Exposures
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-06-03
75
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying whether children treated for retinoblastoma with multiple exposures to anesthesia experience differences in brain development compared to children who have never had anesthesia. The study focuses on cognitive function and neurodevelopment in pediatric retinoblastoma patients. It is an observational study sponsored by Memorial Sloan Kettering Cancer Center. The study does not involve treatment but uses various assessments to evaluate cognitive and behavioral functions. These include the Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V) for overall intellectual ability, the California Verbal Learning Test for verbal learning and memory, the Beery Developmental Test of Visual Motor Integration for visual-motor skills, the Grooved Pegboard Test to measure dexterity, and the Behavior Assessment System for Children/Parent Report to assess social-emotional and behavioral functioning. Participants aged 6 to under 17 years will undergo neuropsychological testing, with scores compared after 6 weeks. Assessments will cover intellectual, memory, motor, and behavioral areas. The study will monitor cognitive outcomes and neurodevelopmental status without intervention, with participation lasting according to the testing schedule. The primary outcome is the comparison of neuropsychological test results to understand any cognitive effects related to anesthesia exposure.
CONDITIONS
Brief Title
Determining Whether Multiple Anesthesia Exposures Affect Cognitive Function for Retinoblastoma Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 6 to less than 17 years old
You will not qualify if you...
- Diagnosis of any secondary disease associated with developmental delay
- History of second cancer diagnosis
- Legal Blindness
- Past surgery of any type, with the exception of enucleation for retinoblastoma
- Past exposure to anesthesia for surgical intervention
- More than one anesthesia encounter for surgical intervention before diagnosis at MSK
- Past External Beam Radiation for treatment of retinoblastoma
- Past systemic chemotherapy
- Non-native speaker of English; however, children whose parents speak only Spanish will be included, because the tests for parents are available in Spanish
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 6 weeks
Participants undergo neuropsychological testing to assess cognitive function using various assessments such as the WISC-V, California Verbal Learning Test, and others.
1 to 2 visits for cognitive assessments
Duration - Up to study completion
Participants are observed over time to compare neuropsychological testing results and assess potential cognitive effects after multiple anesthesia exposures.
Follow-up visits as scheduled for ongoing assessments
Trial Site Locations
Total: 1 location
1
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
Research Team
V
Vittoria Arslan Carlon, MD
D
David Abramson, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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