Studying Brain Development and Cognitive Function in Children Aged 6 to 17 Treated for Retinoblastoma With Multiple Anesthesia Exposures

What this Trial Is About

Researchers are studying whether children treated for retinoblastoma with multiple exposures to anesthesia experience differences in brain development compared to children who have never had anesthesia. The study focuses on cognitive function and neurodevelopment in pediatric retinoblastoma patients. It is an observational study sponsored by Memorial Sloan Kettering Cancer Center. The study does not involve treatment but uses various assessments to evaluate cognitive and behavioral functions. These include the Wechsler Intelligence Scale for Children, Fifth Edition WISC-V for overall intellectual ability, the California Verbal Learning Test for verbal learning and memory, the Beery Developmental Test of Visual Motor Integration for visual-motor skills, the Grooved Pegboard Test to measure dexterity, and the Behavior Assessment System for ChildrenParent Report to assess social-emotional and behavioral functioning. Participants aged 6 to under 17 years will undergo neuropsychological testing, with scores compared after 6 weeks. Assessments will cover intellectual, memory, motor, and behavioral areas. The study will monitor cognitive outcomes and neurodevelopmental status without intervention, with participation lasting according to the testing schedule. The primary outcome is the comparison of neuropsychological test results to understand any cognitive effects related to anesthesia exposure.

Determining Whether Multiple Anesthesia Exposures Affect Cognitive Function for Retinoblastoma Patients