Actively Recruiting
Can Pretreatment MRI be Used to Predict Intra-arterial Chemotherapy Response in Retinoblastoma?
Led by Fondation Ophtalmologique Adolphe de Rothschild · Updated on 2026-01-05
60
Participants Needed
1
Research Sites
650 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Retinoblastoma is the most frequent intraocular tumor in children and represents 6% of all pediatric cancers before the age of 5 years-old. The outcome is now excellent with 95 to 97% of 5-years survival rate. Conservative treatments are being more and more used, and intra arterial chemotherapy is one of the adjuvant treatments proposed to the children. The treatment is efficient in most cases, but a small proportion of children will have an early progression after treatment. MRI is used for the diagnosis of retinoblastoma. We aim to find prognostic factors using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for early identification of children response to intra arterial chemotherapy.
CONDITIONS
Official Title
Can Pretreatment MRI be Used to Predict Intra-arterial Chemotherapy Response in Retinoblastoma?
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of grade B to D retinoblastoma
- Prescription of intra-arterial chemotherapy
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
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Trial Site Locations
Total: 1 location
1
Fondation A De Rothschild
Paris, France, 75019
Actively Recruiting
Research Team
L
Laurence Salomon, MD PhD
CONTACT
A
Augustin Lecler, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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