Clinical Database and Tissue Repository Study for Children with Retinoblastoma Collecting Eye Fluid and Other Samples to Understand and Treat RB

What this Trial Is About

Retinoblastoma RB is a primary eye cancer that develops in the retina of infants and toddlers. This research aims to systematically collect and study clinical data and biological samples from patients diagnosed with unilateral or bilateral retinoblastoma. The goal is to identify molecular markers in the eyes aqueous humor fluid, which may help predict treatment outcomes and improve personalized therapies. The study involves collecting and preserving biomaterials such as aqueous humor, blood, and saliva from patients with retinoblastoma. These samples will be analyzed to detect tumor-derived genetic information without the need for invasive tumor biopsies. Researchers will also record detailed clinical information about each patients presentation, treatment, and outcomes. Participants will be followed through diagnosis and treatment, with outcomes monitored for at least 12 months and on average 24 months. The study will assess correlations between molecular biomarkers and eye salvage, gene mutations, and tumor characteristics. Data collection includes clinical assessments and laboratory analysis of the collected samples to better understand tumor behavior and treatment response over time.

Retinoblastoma Patient Clinical Database and Tissue Repository