Actively Recruiting
DIagnoSing Care hOme UTI Study
Led by University of Southampton · Updated on 2024-07-31
100
Participants Needed
1
Research Sites
82 weeks
Total Duration
On this page
Sponsors
U
University of Southampton
Lead Sponsor
U
University of Oxford
Collaborating Sponsor
AI-Summary
What this Trial Is About
The number of care home residents is increasing and urinary tract infections (UTIs) are common amongst this group. Accurate diagnosis of UTI is important because not treating an infection may lead to serious consequences including death. However, giving antibiotic treatment when there isn't an infection causes side effects and antibiotic resistance, making future infections harder to treat. Unfortunately, there are several challenges that mean that it is difficult to diagnose UTI accurately in care home residents. Firstly, UTIs don't always cause clear symptoms for people who live in care homes. They sometimes just cause symptoms like confusion which can have lots of different possible causes. Secondly, it may be hard for people living with dementia to say how they are feeling or to easily provide a urine sample. Thirdly, many people who live in care homes have bacteria present in their urine even when they are well, but this not harmful and does not need treatment. Finally, urine tests that are currently available do not give accurate or quick results. We have thought about some new ways that might help show us if someone in a care home really has a UTI but we don't know yet whether these will work. Our ideas include 1) Working out which symptoms or signs mean a UTI is more likely 2) Detecting new markers of infection in urine samples and 3) Trying out new bedside tests that give rapid results. For this study we plan to recruit 100 care home residents who will be followed up over 6 months. All 100 participants will provide information and a urine sample at the beginning of the study. 25 of these participants will also provide repeated weekly samples for 4 weeks to look at any changes in the urine over time. Additional information and urine samples will be collected if a participant develops a possible UTI during the study and any treatments will be recorded. Our findings will be used to develop a funding application for a larger study aiming to improve the diagnosis of UTI in care home residents.
CONDITIONS
Official Title
DIagnoSing Care hOme UTI Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing and able to give informed consent for the study, or if lacking capacity, a consultee willing to complete a consultee declaration form.
- Permanently living in a care home (nursing, residential or mixed).
- Aged 65 or over.
You will not qualify if you...
- Current or recent suspected UTI within the last 4 weeks. May be reassessed after 4 weeks.
- Temporary or respite resident unlikely to remain in the care home for 6 months.
- Terminal illness limiting life expectancy as judged by care home staff.
- Medical conditions or treatments causing severe immune system impairment (e.g., neutropenia, recent chemotherapy or radiotherapy, long-term oral steroids or other immunosuppressants).
- Faecal incontinence preventing uncontaminated urine sample collection.
- Indwelling urinary catheter or regular intermittent catheterisation use.
- Structural urological abnormalities such as renal polycystic disease, horseshoe kidney, hydronephrosis, or renal hypoplasia.
- Current renal tract malignancy, except prostate cancer without catheterisation and not terminally ill.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Solent NHS Trust
Southampton, United Kingdom
Actively Recruiting
Research Team
A
Abigail Moore
CONTACT
N
Nick Francis
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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