Actively Recruiting
Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2026-04-13
110
Participants Needed
1
Research Sites
417 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Omega-7 fatty acids are found in the oil extracted from certain fish and nuts like macadamia. Palmitoleic acid is one of the most common omega-7 fatty acids. Many studies suggest that this oil is good for heart health. Researchers want to find out more about these potential benefits. Objective: To study how oil enriched with palmitoleic acid (Omega-7 oil) affects metabolism. Eligibility: Healthy adults at least 18 years old with no known history of cardiovascular disease. Subjects not allergic to fish oil and fish products Females that are not pregnant and are not planning a pregnancy during the length of the study Design: Participants will be screened with questions about their health, medical history, and medicines they take. Participants will have 4 visits over 24 weeks. The visits may include: * Blood drawn from a vein in the arm by a needle stick. Sometimes participants will have to fast before the blood draw. * Vital signs (blood pressure, heart rate, and temperature) taken * Body mass index measured * Cardio-Ankle Vascular Index test may be performed. The stiffness of the participant s arteries will be measured by reading blood pressure in the arms and legs and monitoring the heart. * Optional stool samples * Pregnancy test * A short review of participants physical activity and diet * A supply of dietary supplements to take between visits. Participants will take 4 gel capsules a day. Participants will keep a food and exercise journal Compensation will be provided to subjects that complete the study Check your eligibility for this study by clicking here: https://www.surveymonkey.com/r/DietaryOmega
CONDITIONS
Official Title
Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female participants 18 years of age or above
- Healthy with no known history of cardiovascular disease
- Post-menopausal or women of childbearing potential must be non-lactating and using effective birth control during the study
- Understands the study protocol and provides written informed consent
- Triglyceride levels above 100 mg/dL
You will not qualify if you...
- Pregnant, planning pregnancy during the study, or currently breastfeeding
- Allergy or known sensitivity to fish, omega-3 or omega-7 ethyl esters, or any component of study drugs
- Weight changes greater than 20% over the past 3 months
- Planning significant changes in diet or exercise
- Currently taking more than 2 g per day of MUFA, PUFA, or other fatty acid supplements that may interfere with the study
- Conditions affecting intestinal fat absorption such as chronic diarrhea or gastric bypass
- Acute or life-threatening conditions like recent cardiac arrest, myocardial infarction, stroke, or embolism
- Taking medications or supplements affecting lipoproteins in the past 8 weeks
- Treatment with tamoxifen, estrogens, or progestins not stable for more than 4 weeks
- Initiating new medications or on multiple medications at investigator discretion
- Anticipated surgery during the study
- Elevated liver enzymes above 3 times the upper limit of normal
- Blood donation in the last 2 weeks or planned during the study
- Regular transfusions for any reason
- Any other condition or situation that may compromise safety or data accuracy or noncompliance with protocol directions
- Abnormal baseline lab values considered clinically insignificant by the investigator will not exclude participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
J
Joy Lynne V Freeman
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here