Study of Omega-7 Palmitoleic Acid-Rich Oil Effects on Lipoprotein Metabolism and Appetite in Adults

What this Trial Is About

Researchers are studying how omega-7 fatty acids, especially palmitoleic acid found in certain fish and nuts, affect metabolism and heart health. This pilot, randomized, double-blinded, crossover study aims to see if concentrated palmitoleate oil can improve lipoprotein profiles related to cardiovascular disease risk and influence feelings of fullness or satiety in healthy adults aged 18 and older without cardiovascular disease. Participants will receive two types of oil supplements in separate 8 to 10-week periods with a washout period between them. One group takes control olive oil capsules high in oleic acid, and the other takes palmitoleate-rich oil capsules derived from pollock fish, each dosed as four capsules daily divided into two doses after meals. The study includes 4 outpatient visits over 24 weeks with assessments such as blood draws, vital signs, artery stiffness tests, and optional stool samples. During the study, participants will complete food and exercise journals and have their blood lipids and satiety hormones monitored. Compliance is tracked through pill counts and fatty acid levels in red blood cells. Researchers will measure changes in LDL cholesterol and other lipoproteins, appetite, and related biomarkers. Participants may receive compensation for completing the full 24-week study period.

Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults