Actively Recruiting
Distribution Characteristics of Helicobacter Pylori in Different Gastritis and Early Gastric Cancer States Using Immunohistochemical Staining
Led by Jilin University · Updated on 2025-11-28
231
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
This research aims to analyze how Helicobacter pylori bacteria are distributed in different stages of atrophic gastritis and early gastric cancer. The study uses immunohistochemical staining to examine gastric biopsy samples, seeking to provide guidance for early gastric cancer screening. It involves a retrospective analysis of cases from March 1, 2023, to August 15, 2025, classifying patients based on gastric atrophy and cancer presence. The study involves reviewing immunohistochemical staining results for H. pylori using a specific antibody. Two pathologists independently assess the results, grading bacterial presence from mild to severe based on colonization extent. Cases are grouped into non-atrophic, atrophic, non-open, and open atrophy categories and further classified by early gastric cancer status. The distribution of H. pylori is compared across these groups to identify risk factors linked to early gastric cancer development. Participants had their gastric biopsy samples analyzed for H. pylori presence in different stomach regions. Researchers collect detailed staining data and classify bacterial distribution patterns. The main outcome measured is the H. pylori status one week after endoscopic submucosal dissection (ESD), with secondary outcomes including the percentage of positive H. pylori status in the gastric antrum one year after ESD. The study concludes by using multivariate analyses to identify factors related to early gastric cancer, with all data collected retrospectively.
CONDITIONS
Brief Title
Distribution Characteristics of Helicobacter Pylori
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 80 years
- Tested positive for Helicobacter pylori by immunohistochemical testing at the study center
You will not qualify if you...
- Biopsies not collected from both the greater and lesser curvatures of the gastric antrum and body
- History of stomach surgery
- Suspected autoimmune gastritis under endoscopy
- Liver cirrhosis
- Severe comorbidities such as advanced cancer or renal failure
- Advanced gastric cancer or gastric lymphoma
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Retrospective from March 1, 2023, to August 15, 2025
Participants undergo immunohistochemical testing for Helicobacter pylori using biopsy samples collected from the gastric antrum and body. Results are reviewed by experienced pathologists to assess infection status and distribution characteristics.
1 visit (in-person)
Duration - Up to 1 year after ESD
Participants who tested positive for H. pylori are observed to assess the status of infection and its relation to early gastric cancer development, including follow-up assessments after endoscopic submucosal dissection (ESD).
Follow-up visits up to 1 year after ESD
Trial Site Locations
Total: 1 location
1
the First Hospital of Jilin University
Changchun, Jilin, China, 130021
Actively Recruiting
Research Team
D
Dong Yang, Doctor
H
Hong Xu, Professor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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