Studying Helicobacter pylori Distribution in Different Stages of Gastritis and Early Gastric Cancer Using Special Staining

What this Trial Is About

This research aims to analyze how Helicobacter pylori bacteria are distributed in different stages of atrophic gastritis and early gastric cancer. The study uses immunohistochemical staining to examine gastric biopsy samples, seeking to provide guidance for early gastric cancer screening. It involves a retrospective analysis of cases from March 1, 2023, to August 15, 2025, classifying patients based on gastric atrophy and cancer presence. The study involves reviewing immunohistochemical staining results for H. pylori using a specific antibody. Two pathologists independently assess the results, grading bacterial presence from mild to severe based on colonization extent. Cases are grouped into non-atrophic, atrophic, non-open, and open atrophy categories and further classified by early gastric cancer status. The distribution of H. pylori is compared across these groups to identify risk factors linked to early gastric cancer development. Participants had their gastric biopsy samples analyzed for H. pylori presence in different stomach regions. Researchers collect detailed staining data and classify bacterial distribution patterns. The main outcome measured is the H. pylori status one week after endoscopic submucosal dissection ESD, with secondary outcomes including the percentage of positive H. pylori status in the gastric antrum one year after ESD. The study concludes by using multivariate analyses to identify factors related to early gastric cancer, with all data collected retrospectively.

Distribution Characteristics of Helicobacter Pylori