Actively Recruiting
Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Administered Intravenously in Adult Participants at High Risk of Delayed Graft Function After Kidney Transplantation
Led by Alexion Pharmaceuticals, Inc. · Updated on 2026-04-28
450
Participants Needed
130
Research Sites
181 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary objective of this study is to demonstrate the efficacy of ravulizumab vs placebo in reducing the severity of DGF as measured by time to freedom from dialysis in adult participants who are at high risk of DGF after undergoing transplant of deceased donor kidney.
CONDITIONS
Official Title
Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Administered Intravenously in Adult Participants at High Risk of Delayed Graft Function After Kidney Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older at the time of signing informed consent
- Diagnosed with dialysis-dependent end-stage kidney disease (ESKD)
- Candidate for kidney transplant from donation after circulatory death (DCD) donor
- Candidate for kidney transplant from high-risk donation after brain death (DBD) donor
You will not qualify if you...
- Scheduled to receive a kidney from a donor with category I, II, IV, or V Maastricht Classification
- Diagnosed with stage 3 acute kidney injury (AKI) according to KDIGO guidelines
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 130 locations
1
Research Site
Phoenix, Arizona, United States, 85054
Actively Recruiting
2
Research Site
Los Angeles, California, United States, 90095
Actively Recruiting
3
Research Site
San Francisco, California, United States, 94115
Withdrawn
4
Research Site
San Francisco, California, United States, 94143
Actively Recruiting
5
Research Site
Stanford, California, United States, 94305
Actively Recruiting
6
Research Site
New Haven, Connecticut, United States, 06510
Actively Recruiting
7
Research Site
Jacksonville, Florida, United States, 32224
Actively Recruiting
8
Research Site
Tampa, Florida, United States, 33606
Actively Recruiting
9
Research Site
Atlanta, Georgia, United States, 30322
Actively Recruiting
10
Research Site
Chicago, Illinois, United States, 60608
Actively Recruiting
11
Research Site
Chicago, Illinois, United States, 60637
Actively Recruiting
12
Research Site
Fairway, Kansas, United States, 66205
Actively Recruiting
13
Research Site
Lexington, Kentucky, United States, 40508
Actively Recruiting
14
Research Site
Kenner, Louisiana, United States, 70065
Actively Recruiting
15
Research Site
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
16
Research Site
Detroit, Michigan, United States, 48202
Actively Recruiting
17
Research Site
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
18
Research Site
St Louis, Missouri, United States, 63108
Actively Recruiting
19
Research Site
Omaha, Nebraska, United States, 68198
Actively Recruiting
20
Research Site
Livingston, New Jersey, United States, 07039
Actively Recruiting
21
Research Site
New York, New York, United States, 10016
Withdrawn
22
Research Site
New York, New York, United States, 10065
Actively Recruiting
23
Research Site
Durham, North Carolina, United States, 27705
Actively Recruiting
24
Research Site
Philadelphia, Pennsylvania, United States, 19140
Actively Recruiting
25
Research Site
Greenville, South Carolina, United States, 29605
Actively Recruiting
26
Research Site
Nashville, Tennessee, United States, 37232
Actively Recruiting
27
Research Site
Dallas, Texas, United States, 75235
Actively Recruiting
28
Research Site
Houston, Texas, United States, 77030
Actively Recruiting
29
Research Site
Charlottesville, Virginia, United States, 22908
Actively Recruiting
30
Research Site
Richmond, Virginia, United States, 23298
Actively Recruiting
31
Research Site
Seattle, Washington, United States, 98104
Actively Recruiting
32
Research Site
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
33
Research Site
Buenos Aires, Argentina, 1425
Actively Recruiting
34
Research Site
Buenos Aires, Argentina, B1629AHJ
Actively Recruiting
35
Research Site
Buenos Aires, Argentina, C1431FWO
Actively Recruiting
36
Research Site
Capital Federal, Argentina, C1155ADP
Not Yet Recruiting
37
Research Site
Córdoba, Argentina, X5016LIG
Actively Recruiting
38
Research Site
Adelaide, Australia, 5000
Actively Recruiting
39
Research Site
Brisbane, Australia, 4102
Actively Recruiting
40
Research Site
Camperdown, Australia, 2050
Actively Recruiting
41
Research Site
Murdoch, Australia, 6150
Actively Recruiting
42
Research Site
Innsbruck, Austria, 6020
Actively Recruiting
43
Research Site
Vienna, Austria, 1090
Actively Recruiting
44
Research Site
Belo Horizonte, Brazil, 30130-100
Actively Recruiting
45
Research Site
Belo Horizonte, Brazil, 30150-221
Actively Recruiting
46
Research Site
Botucatu, Brazil, 18618-970
Withdrawn
47
Research Site
Botucatu, Brazil, 18618-970
Actively Recruiting
48
Research Site
Campinas, Brazil, 13083
Actively Recruiting
49
Research Site
Fortaleza, Brazil, 60175295
Actively Recruiting
50
Research Site
Porto Alegre, Brazil, 90035-903
Actively Recruiting
51
Research Site
Porto Alegre, Brazil, 90050-170
Actively Recruiting
52
Research Site
Recife, Brazil, 50070-550
Actively Recruiting
53
Research Site
Rio de Janeiro, Brazil, 1033
Actively Recruiting
54
Research Site
São José do Rio Preto, Brazil, 15090-000
Actively Recruiting
55
Research Site
São Paulo, Brazil, 04036-002
Actively Recruiting
56
Research Site
Edmonton, Alberta, Canada, T6G 2E1
Actively Recruiting
57
Research Site
Vancouver, British Columbia, Canada, V5Z 1M9
Actively Recruiting
58
Research Site
Toronto, Ontario, Canada, M5B 1W8
Actively Recruiting
59
Research Site
Toronto, Ontario, Canada, M5G 2C4
Not Yet Recruiting
60
Research Site
Montreal, Quebec, Canada, H3T 1E2
Not Yet Recruiting
61
Research Site
Guangzhou, China, 510080
Actively Recruiting
62
Research Site
Guangzhou, China, 510260
Actively Recruiting
63
Research Site
Guangzhou, China, 510280
Actively Recruiting
64
Research Site
Hangzhou, China, 310015
Actively Recruiting
65
Research Site
Hengyang, China, 441021
Actively Recruiting
66
Research Site
Nanning, China, 530007
Actively Recruiting
67
Research Site
Shenzhen, China, 518020
Actively Recruiting
68
Research Site
Taiyuan, China, 030032
Withdrawn
69
Research Site
Taiyuan, China, 030032
Not Yet Recruiting
70
Research Site
Tianjin, China, 300192
Actively Recruiting
71
Research Site
Zhengzhou, China, 450003
Actively Recruiting
72
Research Site
Hradec Kralova, Czechia, 50005
Actively Recruiting
73
Research Site
Ostrava, Czechia, 708 52
Actively Recruiting
74
Research Site
Prague, Czechia, 140 21
Actively Recruiting
75
Research Site
Créteil, France, 94000
Withdrawn
76
Research Site
La Rochelle, France, 17019
Withdrawn
77
Research Site
La Tronche, France, 38700
Withdrawn
78
Research Site
Montpellier, France, 34295
Not Yet Recruiting
79
Research Site
Nantes, France, 44093
Withdrawn
80
Research Site
Paris, France, 75651
Withdrawn
81
Research Site
Toulouse, France, 31059
Not Yet Recruiting
82
Research Site
Berlin, Germany, 10117
Actively Recruiting
83
Research Site
Erlangen, Germany, 91054
Actively Recruiting
84
Research Site
Lübeck, Germany, 23538
Actively Recruiting
85
Research Site
Mainz Am Rhein, Germany, 55131
Actively Recruiting
86
Research Site
Münster, Germany, 48149
Actively Recruiting
87
Research Site
Bologna, Italy, 40138
Actively Recruiting
88
Research Site
Milan, Italy, 20122
Actively Recruiting
89
Research Site
Milan, Italy, 20162
Actively Recruiting
90
Research Site
Padova, Italy, 35128
Actively Recruiting
91
Research Site
Parma, Italy, 43100
Actively Recruiting
92
Research Site
Torino, Italy, 10126
Actively Recruiting
93
Research Site
Kyoto, Japan, 602-8566
Actively Recruiting
94
Research Site
Suita-shi, Japan, 565-0871
Actively Recruiting
95
Research Site
Bydgoszcz, Poland, 85-094
Withdrawn
96
Research Site
Gdansk, Poland, 80-214
Actively Recruiting
97
Research Site
Poznan, Poland, 60-355
Actively Recruiting
98
Research Site
Warsaw, Poland, 02-091
Not Yet Recruiting
99
Research Site
Lisbon, Portugal, 1069-166
Actively Recruiting
100
Research Site
Lisbon, Portugal, 1499-005
Actively Recruiting
101
Research Site
Lisbon, Portugal, 1649-035
Not Yet Recruiting
102
Research Site
Porto, Portugal, 4050-313
Actively Recruiting
103
Research Site
Porto, Portugal, 4200319
Actively Recruiting
104
Research Site
Gyeonggi-do, South Korea, 13620
Actively Recruiting
105
Research Site
Seoul, South Korea, 03080
Actively Recruiting
106
Research Site
Seoul, South Korea, 03722
Actively Recruiting
107
Research Site
Badajoz, Spain, 06080
Actively Recruiting
108
Research Site
Barakaldo, Spain, 48903
Actively Recruiting
109
Research Site
Barcelona, Spain, 08025
Actively Recruiting
110
Research Site
Barcelona, Spain, 08035
Actively Recruiting
111
Research Site
Barcelona, Spain, 08036
Actively Recruiting
112
Research Site
Barcelona, Spain, 08907
Not Yet Recruiting
113
Research Site
Barcelona, Spain, 8003
Actively Recruiting
114
Research Site
Cadiz, Spain, 11009
Actively Recruiting
115
Research Site
Córdoba, Spain, 14004
Actively Recruiting
116
Research Site
Granada, Spain, 18014
Actively Recruiting
117
Research Site
Madrid, Spain, 28041
Actively Recruiting
118
Research Site
Málaga, Spain, 29010
Actively Recruiting
119
Research Site
Valencia, Spain, 46009
Actively Recruiting
120
Research Site
Valencia, Spain, 46017
Actively Recruiting
121
Research Site
Zaragoza, Spain, 50009
Actively Recruiting
122
Research Site
Kaohsiung City, Taiwan, 833
Actively Recruiting
123
Research Site
Taichung, Taiwan, 40447
Actively Recruiting
124
Research Site
Taipei, Taiwan, 110
Actively Recruiting
125
Research Site
Taoyuan, Taiwan, 333
Not Yet Recruiting
126
Research Site
Leeds, United Kingdom, LS9 7TF
Actively Recruiting
127
Research Site
London, United Kingdom, E1 1BB
Actively Recruiting
128
Research Site
London, United Kingdom, NW3 2QG
Actively Recruiting
129
Research Site
London, United Kingdom, SE1 9RT
Actively Recruiting
130
Research Site
Woodville South, United Kingdom, 5011
Actively Recruiting
Research Team
A
Alexion Pharmaceuticals, Inc. (Sponsor)
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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