Actively Recruiting
Early Aortic vaLve surgEry Versus wAtchful waitiNg Strategy in Severe Asymptomatic aOrtic reguRgitation
Led by Na Homolce Hospital · Updated on 2026-02-17
217
Participants Needed
8
Research Sites
278 weeks
Total Duration
On this page
Sponsors
N
Na Homolce Hospital
Lead Sponsor
U
University Hospital Hradec Kralove
Collaborating Sponsor
AI-Summary
What this Trial Is About
The optimal timing of surgical intervention in asymptomatic patients with severe aortic regurgitation remains controversial. As per cardiac magnetic resonance assessment, early surgical treatment will be compared with conventional guideline-based strategy in asymptomatic patients with severe aortic regurgitation.
CONDITIONS
Official Title
Early Aortic vaLve surgEry Versus wAtchful waitiNg Strategy in Severe Asymptomatic aOrtic reguRgitation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Chronic asymptomatic aortic regurgitation grade 3 (moderate to severe) or grade 4 (severe)
- No indication for surgical treatment at the time of enrollment
- Left ventricular ejection fraction greater than 50%
- No more than mild-to-moderate other valve disease or complex congenital heart disease
You will not qualify if you...
- Age under 18 years
- Clearance creatinine less than 30 mL/min
- Contraindications for magnetic resonance imaging such as implanted active devices, incompatible ferromagnetic implants, cerebral aneurysm clips, or metallic fragments near sensitive tissues
- Pregnancy
- Permanent atrial fibrillation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
Cardiovascular Center OLV Clinic Aalst
Aalst, Belgium, 9300
Actively Recruiting
2
International Clinical Research Center, St. Anne´s University Hospital Brno
Brno, Czechia, 656 91
Active, Not Recruiting
3
Center of Cardiovascular and Transplant Surgery
Brno, Czechia, 65691
Actively Recruiting
4
University Hospital Hradec Králové
Hradec Králové, Czechia, 50005
Actively Recruiting
5
2nd Department of Internal Cardiovascular Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague
Prague, Czechia, 128 08
Actively Recruiting
6
Na Homolce Hospital
Prague, Czechia, 150 30
Actively Recruiting
7
Nemocnice AGEL Třinec-Podlesí
Třinec, Czechia, 73961
Actively Recruiting
8
University Clinical Center of Serbia
Belgrade, Serbia, 11000
Actively Recruiting
Research Team
R
Radka Kočková, MD,PhD
CONTACT
J
Jan Vojáček, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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