Evaluating Early Ga-68 FAPI PETMR Imaging to Detect Heart Changes After Acute Myocardial Infarction

What this Trial Is About

Acute myocardial infarction AMI triggers a complex heart repair process involving inflammation, activation of fibroblasts, and remodeling of the heart tissue. This remodeling can sometimes lead to harmful changes in the left ventricle of the heart and impaired heart function. Researchers are evaluating the use of a special imaging technique called Ga-68 FAPI PETMR to detect activated fibroblasts early after AMI and to study its association with later changes in heart structure and function. The study involves a single group of patients who have had a recent acute myocardial infarction. Participants will undergo a Ga-68 FAPI PETMR scan approximately 10 days after their heart attack to visualize fibroblast activation. Following this, they will have cardiac magnetic resonance CMR scans at 3 months and 6 months to assess changes in left ventricular remodeling, heart function, infarct details, and heart tissue fibrosis. The imaging findings will be analyzed alongside clinical and laboratory data. Participants will be involved for about 6 months, during which they will receive serial imaging assessments including PETMR and CMR scans. The main measurement is left ventricular remodeling assessed by cardiac magnetic resonance imaging at 6 months. This study aims to determine if early fibroblast activation detected by Ga-68 FAPI PETMR can serve as an early biomarker for predicting heart changes after a heart attack. Safety and clinical outcomes will also be observed throughout the study.

Early Ga-68 FAPI PET/MR After Acute Myocardial Infarction