Actively Recruiting
Clinical and Radiographic Evaluation of Xenograft With Albumin Platelet-Rich Fibrin or Leucocyte- Platelet-Rich Fibrin on Immediate Implant Placement in Mandibular Molar Extraction Sites: Randomized Clinical Trial.
Led by Kafrelsheikh University · Updated on 2025-08-01
20
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to compare two methods of grafting used during immediate dental implant placement in the lower molar region. It focuses on evaluating the effects of xenograft combined with either Albumin Platelet-Rich Fibrin (Alb-PRF) gel or Leucocyte-Platelet-Rich Fibrin (L-PRF) block. The study will assess factors such as peri-implant vertical defect depth, crestal bone level, bucco-lingual bone width, and keratinized tissue width to understand differences between these two grafting techniques. Participants will receive immediate implant placement in the lower molar area, and will be randomly assigned to one of two groups: one receiving grafting with xenograft combined with Alb-PRF gel, and the other with xenograft combined with L-PRF block. Both procedures involve grafting with xenograft material but differ in the type of platelet-rich fibrin used. This study is a randomized clinical trial sponsored by Kafrelsheikh University. Participants will be monitored immediately after surgery and again six months later. During these assessments, researchers will measure vertical peri-implant bone level, crestal bone level, keratinized tissue width, implant stability, and bucco-lingual bone width. These measurements will be taken using clinical and radiographic evaluation methods to determine the effects of the two grafting approaches.
CONDITIONS
Brief Title
Effect of Albumin Platelet-Rich Fibrin or Leucocyte- Platelet-Rich Fibrin on Immediate Implant
Who Can Participate
Eligibility Criteria
You may qualify if you...
- The presence of non-restorable mandibular molar
- Patient 18-45 years old
- Intact buccal and lingual walls
- Good oral hygiene
- Presence of sufficient restorative space
- Jumping gap more than 2 mm
You will not qualify if you...
- Proximity of anatomical structures
- Acute localized infection (suppuration at the surgical field)
- Patients on chemotherapy or radiotherapy
- Patients who have systemic disorders such as diabetes mellitus or autoimmune diseases
- Pregnant patients
- Smoking and alcohol use
- Presence of periapical pathology affecting the neighboring teeth
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Immediate post-operative period
Participants undergo immediate implant placement in the lower molar region, grafted with xenograft combined with either Albumin PRF gel or L-PRF (L-PRF Block).
1 visit (in-person)
Duration - 6 months after surgery
Participants are monitored to evaluate peri-implant bone levels, keratinized tissue width, crestal bone level, implant stability, and bucco-lingual bone width.
1 visit at 6 months post-operative (in-person)
Trial Site Locations
Total: 1 location
1
Kafrelsheikh University, Faculty of Dentistry
Kafr ash Shaykh, Kafrelsheikh, Egypt
Actively Recruiting
Research Team
M
Mostafa Mohamed Fayed, Demonstrator of Periodontology
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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