Study of Autologous Demineralized Dentin Graft With or Without Melatonin Gel for Improving Bone Healing in Immediate Dental Implants in the Upper Premolar Area

What this Trial Is About

This clinical trial studies patients who need extraction and immediate dental implant placement in the upper premolar area. It evaluates the effect of using an autologous demineralized dentin graft ADDG, either alone or combined with melatonin gel, on helping the implant bond with the bone, a process called osseointegration. The study aims to see if melatonin, an antioxidant that may promote bone healing, improves implant success and healing outcomes over 9 months. Participants will be randomly assigned to one of two groups. One group receives immediate implant placement with the gap around the implant filled using ADDG alone, made from the patients extracted tooth processed into graft material. The other group receives the same graft mixed with melatonin gel applied locally around the implant. Both groups will have their implants placed in the maxillary premolar region using standard surgical techniques. Throughout the 9-month follow-up, patients will undergo clinical exams and imaging to measure implant stability, gum health, bone loss, bone thickness, and bone density at various times. Assessments include probing depth, bleeding index, and cone beam CT scans. The study tracks changes from baseline to 6 and 9 months after implant placement to compare healing and bone integration between the two treatment methods.

Autologous Demineralized Dentin Graft With or Without Melatonin for Immediate Implant Osseointegration