Cannabis Extract for Treating Acute Radicular Back Pain and Renal Colic Pain with Painkiller Reduction A Double-Blind, Randomized 24-Hour Study

What this Trial Is About

Researchers are studying the effects of cannabis extract, specifically a combination of tetrahydrocannabinol THC and cannabidiol CBD, on acute radicular back pain and renal colic pain. The study aims to evaluate whether cannabis can reduce pain and decrease the need for opioid painkillers in patients experiencing strong nerve-related pain or pain due to kidney stones. This is a randomized, double-blinded clinical trial including adult patients hospitalized for these acute pain conditions. Participants will receive one of several treatments a high dose of cannabis oil 21.6 mg THC and 20 mg CBD, a split high dose given one hour apart, a low dose 10.8 mg THC and 10 mg CBD, or a placebo consisting of olive oil with a similar taste and appearance. All patients will also receive standard pain management with morphine via a patient-controlled analgesia PCA pump over 24 hours. The treatments are administered under the tongue, and blinding is maintained for patients, researchers, and analysts. During the study, patients will be monitored for their opioid consumption over 24 hours using the PCA pump, which is the primary outcome. Secondary outcomes include changes in nausea, vomiting, anxiety, and pain intensity measured by visual analog scales VAS. Safety and effectiveness will be assessed throughout the 24-hour follow-up period while patients continue their standard care. The study is sponsored by Hadassah Medical Organization and includes adults aged 18 to 70 years with acute radicular pain or renal colic.

Effect of Cannabis Extract on Acute Radicular Pain and on Analgesic Requirement