Actively Recruiting
Studying How Oral Dronabinol Affects Men and Women Differently in Healthy Adults Ages 18 to 55
Led by Yale University · Updated on 2025-06-10
40
Participants Needed
1
Research Sites
26 weeks
Total Duration
AI-Summary
What this Trial Is About
This research aims to explore how oral Dronabinol, a form of Delta-9-Tetrahydrocannabinol THC, affects healthy adults differently based on gender. The study focuses on understanding the immediate effects of cannabinoids in women compared to men and investigating the biological reasons behind any observed gender differences. Participants will receive either a 10 mg oral capsule of Dronabinol or a placebo pill containing no active cannabinoids. The study is randomized and includes a placebo-controlled group. The treatment effects will be monitored at specific timepoints following administration to assess changes in subjective feelings of being high and verbal learning abilities. During the study, participants will be evaluated using the Visual Analog Scale VAS to measure rewarding effects at multiple intervals up to 300 minutes after taking the dose. Verbal learning will be assessed using the Rey Auditory Verbal Learning Test RAVLT at baseline and 80 minutes after dosing. The trial is designed to carefully track these outcomes to understand the acute effects of cannabinoids and any gender-related differences.
CONDITIONS
Brief Title
Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study I
Research Team
C
Carly Hewes, BS
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