Study of Laparoscopic Splenectomy to Improve Liver Function in Adults with Cirrhosis and Enlarged Spleen

What this Trial Is About

This research aims to evaluate the improvement of liver reserve function indicators in patients with liver cirrhosis after they undergo laparoscopic splenectomy. The goal is to understand whether this surgical treatment can help enhance liver function after surgery and improve the overall outlook for these patients. The study includes patients diagnosed with cirrhosis and splenomegaly with related blood cell count issues. Patients will receive laparoscopic splenectomy performed by the same surgical team, followed by standardized nursing care. After surgery, all patients will get a consistent treatment plan including medications and other therapies. Liver reserve function will be monitored before surgery and at 3, 6, 12, and 24 months afterward, measuring various blood and liver function indicators such as TBIL, DBIL, ALB, ALT, INR, PT, Child-Pugh score, ascites, prealbumin, and specific liver function tests like ICG-K, ICG-R15, and ICG-T2. Participants will provide general health information and undergo assessments at several time points after surgery. The research team will conduct blood tests and liver function evaluations to track changes over two years. The main measures are liver reserve function levels at 3, 6, 12, and 24 months after surgery. This study is sponsored by Northern Jiangsu Peoples Hospital and involves ongoing follow-up to monitor patient progress and liver function.

The Effect of Laparoscopic Splenectomy on Liver Reserve Function for Cirrhosis Patients