Study of Transcranial Alternating Current Stimulation to Improve Brain Function in Early Alzheimers Disease A Randomized, Double-Blind Trial with Daily Treatment for 14 Days

What this Trial Is About

Researchers are evaluating the effects and brain mechanisms of transcranial alternating current stimulation tACS in people with early Alzheimers disease. This study uses a randomized, double-blind design to compare real tACS treatment with a sham procedure, aiming to understand how this non-invasive brain stimulation affects cognition and symptoms in mild Alzheimers cases. Participants are randomly assigned to receive either real tACS or sham tACS once daily for 14 consecutive days. Real tACS involves applying weak alternating electrical currents to the brain, while the sham group receives only brief ramp-up and ramp-down stimulation without ongoing current. Both groups undergo treatment at the First Affiliated Hospital of Anhui Medical University with masking to ensure unbiased assessments. Before treatment, patients complete a comprehensive set of cognitive, memory, emotional, and behavioral tests, including the Alzheimers Disease Assessment Scale-Cognitive Subscale ADAS-Cog as the primary outcome. Resting EEG data is collected, and assessments are repeated immediately after treatment and again two months later to measure changes. Safety and tolerability are monitored throughout. The main goal is to track cognitive changes and brain activity over a 12-week period following the treatment.

Effect of Transcranial Alternating Current Stimulation(tACS) for Early Alzheimer's Disease