Actively Recruiting
The Improvement Effect of Vitamin D on the Cardiovascular Health of Overweight/Obesity Adolescents in China
Led by Anhui Medical University · Updated on 2025-11-17
130
Participants Needed
2
Research Sites
2 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating whether vitamin D3 supplementation can improve cardiovascular metabolic health in Chinese adolescents who are overweight or obese and have vitamin D deficiency. This randomized controlled trial aims to compare changes in cardiometabolic risk between those receiving vitamin D3 and those receiving a placebo over a 12-week period. Participants will be randomly assigned to receive either vitamin D3 supplements or a placebo. The vitamin D3 group will take 2000 IU daily for the first 6 weeks, followed by 800 IU daily for the next 6 weeks. The placebo group will receive matching placebo capsules on the same schedule. For the first 6 weeks, doses are given every two weeks, then every three weeks for the following 6 weeks. During the study, researchers will monitor changes in cardiometabolic risk scores from the start to the end of the 12-week intervention. Additional measurements include body mass index, waist circumference, skinfold thickness, blood pressure, blood glucose, blood lipids, and the TyG index. Participants’ health and vitamin D levels will be assessed throughout to evaluate the effects of supplementation.
CONDITIONS
Brief Title
Effect of Vitamin D on Cardiovascular Metabolic Risk in Overweight/Obesity Adolescents in China
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Students whose caregivers signed informed consents
- Students with serum 25(OH)D concentration of 12-20 ng/mL
- Students with overweight or obesity
You will not qualify if you...
- Students with any disease that affects vitamin D metabolism (e.g., functional/organic brain disease, severe infectious disease, chronic gastrointestinal disease, hepatic or renal insufficiency, etc.)
- Students with known chronic disease (e.g., cardiovascular disease)
- Use of vitamin D supplements in the past 3 months
- Students with allergies to vitamin D or soybean oil ingredients
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 12 weeks
Participants receive daily vitamin D3 supplementation or placebo for 12 weeks to evaluate effects on cardiovascular metabolic health.
Visits every 2 weeks during the first 6 weeks, then every 3 weeks for the next 6 weeks
Trial Site Locations
Total: 2 locations
1
Anhui Medical University
Anqing, Anhui, China
Actively Recruiting
2
Anhui Medical University
Hefei, Anhui, China
Actively Recruiting
Research Team
P
Puyu Su, PhD
P
Puyu Su, Professor
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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